Results 111 to 120 of about 1,467,776 (267)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Prevalence of occupational injuries among workers in the iron and steel industries in Tanzania
Annals of Global HealthBackground: In Tanzania, iron and steel manufacturing industries are based on manual work with minor automation, as workers segregate scrap metals and add them to furnaces for melting.
Saumu Shabani +3 more
doaj +1 more source
Creative Industries Innovation Centre Case Study - Interaction Consortium.pdf
, 2015 In 2011, the Creative Industries Innovation Centre worked with its industry partners to select 50 high potential creative enterprises from around the nation to participate in a series of business model workshops.
Creative Industries Innovation Centre
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
CIIC Submission - Satellite Accounts Discussion Paper - August 2013.pdf
, 2015 Creative Industries Innovation Centre submission regarding ABS Discussion paper, Cultural & Creative Activity Satellite Accounts. Specifically responds to 'Component 1 - Cultural and Creative Industry Supply Chains' and 'Component 2 - Cultural and ...
Creative Industries Innovation Centre
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
The Public Sector´s Structure of Production and Its Changes: the Czech Case [PDF]
Statistika: Statistics and Economy Journal, 2017 The public sector in its role as a producer has been expanding beyond the provision of public goods only. Currently, public producers are engaged in almost all activities as they are classified in the NACE classification.
Václav Rybáček
doaj
, 2015 Creative Industries Innovation Centre services flyer ...
Creative Industries Innovation Centre
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source