Results 91 to 100 of about 153,669 (262)

Effects of Shift Work on Health and Satisfaction of Workers in the Mining Industry

International Journal of Occupational Hygiene, 2017
The negative consequences of shift work on workers’ health and safety increasingly ignored. The major effects include health effects and effects on quantity of sleep, alertness, life satisfaction, and job performance.
LEILA OMIDI, SAJAD ZARE, ROHADIN MORADI RAD, MOHSEN MESHKANI, SABA KALANTARY   +4 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A new roadmap for an age-inclusive workforce management practice and an international policies comparison [version 2; peer review: 2 approved]

Open Research Europe
Background Worldwide, the worker population age is growing at an increasing rate. Consequently, government institutions and companies are being tasked to find new ways to address age-related workforce management challenges and opportunities.
Nicola Berti, Niloofar Katiraee, Patrick Neumann, Ilenia Zennaro, Ajay Das, Vlado Dimovski, Riccardo Aldrighetti, Debra Dobbs, Darja Peljhan, Gail Pacheco, Christoph Glock, Ami Ogawa, Daria Battini   +12 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Development of abnormal diagnosis and factory evaluation standards for RV reducer based on vibration characteristics

Scientific Reports
Vibration characteristics are important reference indicators for reflecting the overall performance of RV reducers. At present, there is no factory testing standard for vibration characteristics applicable to production enterprises in the industry.
Xin Wang, Chunlei Li, Suben Lin
doaj   +1 more source

Mental health status of workers in the semiconductor industry during the COVID-19 pandemic: comparisons between regions on three continents

Frontiers in Public Health
BackgroundThe COVID-19 pandemic had detrimental effects on mental health globally, both in and outside the work context. The type of work and work organization additionally had adverse or protective effects on mental health, with sometimes inconsistent ...
Lisbeth Weitensfelder, Michael Kundi, Siegfried Knasmueller, Armen Nersesyan, Michael Schneider, Georg Wultsch   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Development of Representative Sailing Mode Construction Methodology Using Markov Chain

Journal of Marine Science and Engineering
The strengthening of regulations such as EEXI, EEDI, and CII on ship emissions is underway. Despite their application, objective comparisons of ships are hindered by diverse navigation patterns and varying velocity regulations in different seas and ports.
Changjae Moon, Sanghun Jeong, Giltae Roh, Kido Park   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source