Results 41 to 50 of about 42,352 (253)

Validation of Support for Creation of License Drawings Using Application for openBIM-Based Automatic Generation of 2D Drawings

Applied Sciences, 2020
In the preparation of drawings and documents required for a licensing process, the main problem is the duplication of work in creating design drawings and Building Information Modeling (BIM) models. To overcome this problem, BIM authoring tools provide a
Inhan Kim, Yongha Lee, Choong-Hee Han, Gutaek Kim, Jungsik Choi   +4 more
doaj   +1 more source

An Automatic Generation Method of Finite Element Model Based on BIM and Ontology

Buildings, 2022
For the mechanical analysis work in the structural design phase, data conversion and information transfer between BIM model and finite element model have become the main factors limiting its efficiency and quality, with the development of BIM (building ...
Jing Jia, Jieya Gao, Weixin Wang, Ling Ma, Junda Li, Zijing Zhang   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

An ontology-based analysis of the industry foundation class schema for building information model exchanges [PDF]

Advanced Engineering Informatics, 2015
Robust knowledge sharing frameworks between different stakeholders in a building project is of high priority. Industry Foundation Classes (IFC) provides a rich schema for interoperability through object-based transactions. However, IFC lacks semantic clarity in mapping entities and relationships, resulting in multiple definitions to map the same ...
Manu Venugopal, Charles M. Eastman, Jochen Teizer   +2 more
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Automated IFC Generation and Machine Learning-Based λ-Correction for Embodied Carbon Estimation of Buildings [PDF]

E3S Web of Conferences
This study proposes a practical framework for estimating embodied carbon in buildings by integrating automated generation of Industry Foundation Classes (IFC) models with X-correction techniques.
Kang Chanhyeok, Jung Bokyung, Lee Taekyu, Kwon Youngcheol, Choi Changho   +4 more
doaj   +1 more source

A Core System for Design Information Management Using Industry Foundation Classes

Computer-Aided Civil and Infrastructure Engineering, 2003
Research has been conducted for the appli- cations of Industry Foundation Classes (IFC), developed by International Alliance for Interoperability (IAI) for building product model-based information sharing and exchange. This article presents the results and lessons learned from a research project, titled "A Development of the 3D Object-Based Product ...
Keunhyoung Lee, Sangyoon Chin, Jaejun Kim   +2 more
openaire   +1 more source