Results 41 to 50 of about 5,983,116 (281)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A New Building Information Modelling-Based Approach to Automate Recyclability Rate Calculations for Buildings

Buildings
To address environmental challenges, the Architecture, Engineering, Construction, and Operations (AECO) industry, which is known for its high resource consumption and waste production, needs to switch to a circular economy (CE).
Alireza Fereydooni Eftekhari, Ania Khodabakhshian, Ornella Iuorio, Fulvio Re Cecconi, Bruno Daniotti   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Validation of Support for Creation of License Drawings Using Application for openBIM-Based Automatic Generation of 2D Drawings

Applied Sciences, 2020
In the preparation of drawings and documents required for a licensing process, the main problem is the duplication of work in creating design drawings and Building Information Modeling (BIM) models. To overcome this problem, BIM authoring tools provide a
Inhan Kim, Yongha Lee, Choong-Hee Han, Gutaek Kim, Jungsik Choi   +4 more
doaj   +1 more source

An Automatic Generation Method of Finite Element Model Based on BIM and Ontology

Buildings, 2022
For the mechanical analysis work in the structural design phase, data conversion and information transfer between BIM model and finite element model have become the main factors limiting its efficiency and quality, with the development of BIM (building ...
Jing Jia, Jieya Gao, Weixin Wang, Ling Ma, Junda Li, Zijing Zhang   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Irish Hospice Foundation Annual Report 2020

, 2021
Every death matters – and we only have one chance to get it right. Many of the experiences of dying, death and bereavement during 2020 fell very far short of the expressed wishes of the Irish people in relation to what they want for themselves or their ...
Irish Hospice Foundation
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An ontology-based analysis of the industry foundation class schema for building information model exchanges [PDF]

Advanced Engineering Informatics, 2015
Robust knowledge sharing frameworks between different stakeholders in a building project is of high priority. Industry Foundation Classes (IFC) provides a rich schema for interoperability through object-based transactions. However, IFC lacks semantic clarity in mapping entities and relationships, resulting in multiple definitions to map the same ...
Manu Venugopal, Charles M. Eastman, Jochen Teizer   +2 more
openaire   +1 more source