Results 41 to 50 of about 674,800 (303)

Shaping 21st Century Journalism: Leveraging a "Teaching Hospital Model" in Journalism Education [PDF]

, 2011
Calls on journalism programs to become "anchor institutions" in the digitally networked age by pursuing a broader, community-oriented mission, testing new journalism models, exploring how journalistic ecosystems evolve, and shaping policymaking ...
C. W. Anderson, Jason Smith, Marika Rothfeld, Tom Glaisyer   +3 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

A Scientific Roadmap for Antibiotic Discovery: A Sustained and Robust Pipeline of New Antibacterial Drugs and Therapies is Critical to Preserve Public Health [PDF]

, 2016
In recent decades, the discovery and development of new antibiotics have slowed dramatically as scientific barriers to drug discovery, regulatory challenges, and diminishing returns on investment have led major drug companies to scale back or abandon ...
Allan Coukell, Carolyn Shore, Elizabeth Jungman, Kathy Talkington, Pooja Kothari, Susan K. Urahn   +5 more
core  

Simple Building Information Modeling by using Industry Foundation Classes [PDF]

, 2018
Building Information Modeling (BIM) is a rising technology, already widely used in AEC & HVAC industry around the world. The basic idea of BIM, to create, store and use the building information efficiently is currently the work in progress. Namely, a significant amount of relevant information about the building is impossible to create or use by the ...
Isailović, Dušan, Svetel, Igor
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Analyzing the Impact of ISO 16739-1:2024 (Industry Foundation Classes, IFC) on Data Sharing and Building Information Modeling (BIM) Collaboration in the Construction Industry

Journal of Architectural Sciences and Applications
This study conducts a comprehensive analysis of ISO 16739-1:2024 (Industry Foundation Classes, IFC) within the context of Building Information Modeling (BIM) in the construction industry.
Murat Aydın
doaj   +1 more source

Through the Eye of a Needle: The Challenge of Providing Employment Services in New York's Chinatown Post September 11th [PDF]

, 2003
Prepared for the US Department of Labor, this P/PV report evaluates the effectiveness of the National Emergency Grant (NEG) money awarded to organizations in Chinatown in the wake of September 11th.
Mark Elliott, Shayne Spaulding
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A New Building Information Modelling-Based Approach to Automate Recyclability Rate Calculations for Buildings

Buildings
To address environmental challenges, the Architecture, Engineering, Construction, and Operations (AECO) industry, which is known for its high resource consumption and waste production, needs to switch to a circular economy (CE).
Alireza Fereydooni Eftekhari, Ania Khodabakhshian, Ornella Iuorio, Fulvio Re Cecconi, Bruno Daniotti   +4 more
doaj   +1 more source