Results 101 to 110 of about 624,295 (329)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Frontiers in Mechanical EngineeringIntroduction: With the rapid development of human society and economy, the power generation technology of various new energy vehicles has begun to receive widespread attention.Methods: Due to the lack of inertia and frequency stability in the new energy ...
Meng Du, Hailong Mei
doaj +1 more source
A novel control strategy of virtual synchronous generator in island micro-grids
Systems Science & Control Engineering, 2018 The control strategy of virtual synchronous generator (VSG) is an effective and efficient technique to provide frequency supporting for distributed generations.
Yong-jin Yu, Li-ke Cao, Xingmin Zhao
doaj +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
A psychological law of inertia and the illusion of loss aversion [PDF]
Judgment and Decision Making, 2006 The principle of loss aversion is thought to explain a wide range of anomalous phenomena involving tradeoffs between losses and gains. In this article, I show that the anomalies loss aversion was introduced to explain --- the risky bet premium, the ...
David Gal
doaj
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Science and Technology for Energy TransitionThe grid-connected capacity of renewable energy generation in multi-energy microgrid is increasing. This leads to a decrease in the inertia level in the microgrid, which has a great impact on the frequency stabilization control.
Zuo Hao, Teng Yun, Chen Zhe
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Constrained operation zone of a VSG considering the DC-side power margin
The Journal of Engineering, 2019 Recently, the virtual synchronous generator (VSG) has drawn considerable attention for its function of simulating the electromechanical transient of SG to make converters equip with the characters of inertia, damping, voltage regulating, and frequency ...
Chang Yuan +3 more
doaj +1 more source
Experimental determination of airplane mass and inertial characteristics [PDF]
Current practices are evaluated for experimentally determining airplane center of gravity, moments of inertia, and products of inertia. The techniques discussed are applicable to bodies other than airplanes.
Wolowicz, C. H., Yancey, R. B.
core +1 more source