Results 91 to 100 of about 195,236 (290)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The application of virtual synchronous generator technology in inertial control of new energy vehicle power generation

Frontiers in Mechanical Engineering
Introduction: With the rapid development of human society and economy, the power generation technology of various new energy vehicles has begun to receive widespread attention.Methods: Due to the lack of inertia and frequency stability in the new energy ...
Meng Du, Hailong Mei
doaj   +1 more source

A psychological law of inertia and the illusion of loss aversion [PDF]

Judgment and Decision Making, 2006
The principle of loss aversion is thought to explain a wide range of anomalous phenomena involving tradeoffs between losses and gains. In this article, I show that the anomalies loss aversion was introduced to explain --- the risky bet premium, the ...
David Gal
doaj  

Influence of Total Inertia Effects in a Thrust Curvilinear Bearing Lubricated with Newtonian Lubricants [PDF]

, 2017
In the paper, the flow of a Newtonian type of lubricant in the clearance of a curvilinear bearing is considered. It is assumed that the bearing walls are modelled as smooth and impermeable.
A. Walicka, Walicka, A., P. Jurczak, Jurczak, P.   +3 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Frequency stability control method for multi-energy system considering storage characteristics and transmission inertia of hot and gas pipeline network

Science and Technology for Energy Transition
The grid-connected capacity of renewable energy generation in multi-energy microgrid is increasing. This leads to a decrease in the inertia level in the microgrid, which has a great impact on the frequency stabilization control.
Zuo Hao, Teng Yun, Chen Zhe
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Effects of muscle mass on muscle force predictions in human movementEffects of muscle mass on muscle force predictions in human movement [PDF]

Royal Society Open Science
Muscle mass significantly influences skeletal muscle behaviour, potentially explaining why traditional massless Hill-type models struggle to predict the forces generated by larger muscles during dynamic, submaximal contractions.
Chen Ing-Jeng, Ameur Latreche, Stephanie A. Ross, Javier A. Almonacid, Taylor J. M. Dick, Evie Vereecke, James M. Wakeling   +6 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source