Results 91 to 100 of about 610,137 (277)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A matrix approach to determine optimal predictors in a constrained linear mixed model

Open Mathematics
For a general vector of all unknown vectors in a constrained linear mixed model (CLMM), this study compared the dispersion matrices of the best linear unbiased predictors with any symmetric matrix for determining the optimality of predictors among others.
Güler Nesrin, Büyükkaya Melek Eriş
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Therapeutic inertia in the management of patients with moderate to severe psoriasis: A systematic review of cross‐sectional studies

JEADV Clinical Practice
Therapeutic inertia (TI) is defined as the inability of physicians to intensify or initiate a more aggressive treatment in patients who need it. This study aims to explore the evidence behind TI in the management of patients with moderate to severe ...
Jennifer Lavina Ngo, Czarina Chavez
doaj   +1 more source

High-speed pulse camera [PDF]

, 1968
Miniaturized, 16 mm high speed pulse camera takes spectral photometric photographs upon instantaneous command. The design includes a low-friction, low-inertia film transport, a very thin beryllium shutter driven by a low-inertia stepper motor for ...
Lawson, J. R.
core   +1 more source

Spontaneous phase oscillation induced by inertia and time delay

, 2001
We consider a system of coupled oscillators with finite inertia and time-delayed interaction, and investigate the interplay between inertia and delay both analytically and numerically.
D. V. Ramana Reddy, E. Niebur, Gun Sang Jeon, H. Daido, H. Daido, H. Hong, H. Hong, H. Hong, H. Hong, H.-A. Tanaka, J. A. Acebron, K. Park, M. K. S. Yeung, M. Y. Choi, M. Y. Choi, S. Kim, Y. Kuramoto, Y. Nakamura   +17 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

About Body Inertness [PDF]

Философия и космология, 2016
The article investigates and further develops the Newton’s hypothesis about the origin of inertial forces. For this purpose the classic interpretation of light aberration phenomenon and the Lorentz — FitzGerald hypothesis — proposed to explain the ...
Alexandr Izbreht
doaj  

On the bipenalty method: why is it advantageous to add stiffness and mass [PDF]

, 2011
In a recent paper, Askes et al [1] proposed the simultaneous use of stiffness and inertia of large magnitude to model constraints in time domain analysis.
Ilanko, Sinniah, Monterrubio Salazar, Luis Emilio   +1 more
core   +1 more source