Results 101 to 110 of about 195,236 (290)

Modeling inertia causatives [PDF]

, 2019
Cyber criminals are benefiting from the fact that people do not take the required precautions to protect their devices and communications. It is the equivalent of leaving their home's front door unlocked and unguarded, something no one would do.
Renaud, Karen, Ophoff, Jacques, Vance, Anthony   +2 more
core   +1 more source

Caught on the Back Foot: epistemic inertia and visible music

IASPM Journal, 2011
This paper explores the position of popular music studies thirty years since the formation of the International Association for the Study of Popular Music. Founder member of the association, Phillip Tagg, discusses what issues need to be addressed in the
Philip Tagg
doaj   +1 more source

Optimal CO2-abatement with socio-economic inertia and induced technological change [PDF]

The impact of induced technological change (ITC) in energy/climate models on the timing of optimal CO2-abatement depends on whether R&D or learning-by-doing (LBD) is the driving force. Bottom-up energy system models employing LBD suggest strong increases
Richard S.J. Tol, Malte Schwoon
core  

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

The Socio-Technical Dimension of Inertia in Digital Transformations [PDF]

, 2017
When organizations undertake large transformation initiatives enabled by information technology, these efforts are often hampered by inertia. The literature suggests that inertia plays a dual role in organizations: it is both required for organizational ...
Recker, Jan, Alexander M. Schmid, Jan vom Brocke, Schmid, Alexander M., Jan Recker, vom Brocke, Jan   +5 more
core   +2 more sources

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Quantitative Difference Between the Effective Inertia and Set Inertia Parameter of Virtual Synchronous Generators

Energies
Virtual synchronous generators (VSGs) have been developed to mitigate the increase in the rate of change of frequency (ROCOF) in power systems by replacing synchronous generators (SGs) with inverter-based resources. VSGs mimic the dynamics and control of
Ryosuke Shikuma, Dai Orihara, Hiroshi Kikusato, Akihisa Kaneko, Hisao Taoka, Yasuhiro Hayashi   +5 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source