Results 41 to 50 of about 195,236 (290)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Geosciences, 2020 Snow avalanches are catastrophic phenomena because of their destructive power. Therefore, it is very important to forecast the affected area of snow avalanches using numerical simulations.
Kae Tsunematsu +2 more
doaj +1 more source
Energies, 2021 Renewable integration into the electricity system of Great Britain (GB) is causing considerable demand for additional flexibility from plants. In particular, a considerable share of this flexibility may be dispatched to secure post-fault transient ...
Mohamed Hadri +4 more
doaj +1 more source
Ambient Synchrophasor Measurement Based System Inertia Estimation
, 2020 This paper develops an algorithm to estimate the system inertia value based on ambient synchrophasor measurement. Informative features are extracted from ambient synchrophasor measurements for machine-learning-based inertia estimation.
Yi Cui +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Inertia and Decision Making [PDF]
Frontiers in Psychology, 2016 Decision inertia is the tendency to repeat previous choices independently of the outcome, which can give rise to perseveration in suboptimal choices. We investigate this tendency in probability-updating tasks. Study 1 shows that, whenever decision inertia conflicts with normatively optimal behavior (Bayesian updating), error rates are larger and ...
Alós-Ferrer, Carlos +2 more
openaire +3 more sources
Overload Mitigation of Inertial Grid-Forming Inverters Under Frequency Excursions
Applied SciencesGrid-forming (GFM) inverters play a critical role in stabilizing future power grids. However, their synchronization is inherently coupled with frequency support, which poses a challenge to prevent overloading while maintaining synchronization.
Ander Ordono +4 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source