Results 91 to 100 of about 49,035 (294)

The effect of non-linear inertia on dynamic response of asymmetric multi-story buildings [PDF]

, 2018
The goal of this paper is to inspect the influence of non-linear inertia on dynamic response of multi-story asymmetric buildings. In this study unlike conventional linear approach, the non-linear inertial terms are considered in the equations of motion ...
Fereidoun Amini, Hassan Rezazadeh
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

An Adaptive Inertia and Damping Control Strategy for Virtual Synchronous Generators to Enhance Transient Performance

Energies
Virtual synchronous generator (VSG) technology introduces synthetic rotational inertia and damping into inverter-based systems, thereby enhancing regulation performance under grid-connected operation.
Wenzuo Tang, Bo Li, Xianqi Shao, Yun Ye, Yue Yu, Jiawei Chen   +5 more
doaj   +1 more source

Power System Inertia Estimation and Frequency Response Assessment [Elektronisk resurs] [PDF]

, 2019
Power plant emissions constitute a major source of environmental pollution. This renders the gradual replacement of such power plants by renewable energy sources imperative.
Ghandhari, Mehrdad, Zografos, Dimitrios,, Terzija, Vladimir,   +2 more
core  

How Dynamic Consumer Response, Competitor Response, Company Support, and Company Inertia Shape Long-Term Marketing Effectiveness [PDF]

Long-term marketing effectiveness is a high-priority research topic for managers, and emerges from the complex interplay among dynamic reactions of several market players.
Koen Pauwels
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Multi-objective configuration and evaluation of dynamic virtual inertia from DFIG based wind farm for frequency regulation

International Journal of Electrical Power & Energy Systems
Modern power systems are gradually evolving into low-inertia systems due to the integration of high penetration of renewable energy and power electronic equipment.
Chao Jiang, Guowei Cai, Dongfeng Yang, Xiaojun Liu, Shuyu Hao, Bohan Li   +5 more
doaj   +1 more source

Optimal CO2-abatement with socio-economic inertia and induced technological change [PDF]

The impact of induced technological change (ITC) in energy/climate models on the timing of optimal CO2-abatement depends on whether R&D or learning-by-doing (LBD) is the driving force. Bottom-up energy system models employing LBD suggest strong increases
Richard S.J. Tol, Malte Schwoon
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source