Results 171 to 180 of about 517,956 (289)

Population pharmacokinetics of levofloxacin in breastmilk in patients with rifampicin‐resistant tuberculosis

British Journal of Clinical Pharmacology, EarlyView.
Levofloxacin is a widely used antibiotic included in rifampicin‐resistant tuberculosis (RR‐TB) treatment. Data describing levofloxacin concentrations in breastmilk and infant exposure are limited. We analysed data from two South African studies of breastfeeding women receiving levofloxacin (750–1000 mg daily) for RR‐TB.
Sharon Sawe, Lufina Tsirizani, Buyisile Mkhize, Lubbe Wiesner, Gary Maartens, Francesca Conradie, Richard Court, Marian Loveday, Catriona Waitt, Paolo Denti   +9 more
wiley   +1 more source

Infant Food Hygiene and Childcare Practices in Context: Findings from an Urban Informal Settlement in Kenya. [PDF]

Am J Trop Med Hyg, 2020
Mumma JAO, Cumming O, Simiyu S, Czerniewska A, Aseyo RE, Muganda DN, Davis E, Baker KK, Dreibelbis R.   +8 more
europepmc   +1 more source

Population pharmacokinetic modelling of amoxicillin in human breast milk—A contribution from the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti, Virginie Rigourd, Alice Panchaud, Hedvig Nordeng, Karel Allegaert, Pieter Annaert, Miao‐Chan Huang, Anaelle Monfort, Monia Guidi, Peggy Gandia   +9 more
wiley   +1 more source

Nutrition and obesity in under-represented population (NOURISH): study protocol to examine the effect of restricted and unrestricted financial benefits on infant food insecurity, growth, and nutrition. [PDF]

BMC Pediatr
Chen K, Skinner AC, Bryant S, Granados I, Cholera R, Drake C, Howard JB, Kay MC, Ksor M, Neshteruk CD, Newgard CB, Ravanbakht S, Scherr KA, Truong T, Wood CT, Armstrong SC.   +15 more
europepmc   +1 more source

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

British Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon, Hinke Huisman‐Siebinga, Shelby Barnett, Paul Wetherell, Pamela Kearns, Brenda Gibson, Nicholas Heaney, Owen Smith, André Baruchel, Arnaud Petit, Andrew Moore, Kayode Ogungbenro, Alwin D. R. Huitema, Gareth J. Veal   +13 more
wiley   +1 more source

Interventions to mitigate infant food insecurity in high-income countries: an overview of current evidence. [PDF]

Nutrire
Singal K, Douglas F, Mackie P, Paranjothy S, Brazzelli M.   +4 more
europepmc   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Carrot Powder and Jaggery Supplemented Germinated Oat, Teff Based Complementary Infant Food: Formulation, Optimization, and Characterizations. [PDF]

Food Sci Nutr
Duraisamy R, Bekele B, Haile B, Mulugeta E, Mada T.   +4 more
europepmc   +1 more source

Deciphering infant mortality. Part 1: empirical evidence

, 2016
This paper is not (or at least not only) about human infant mortality. In line with reliability theory, "infant" will refer here to the time interval following birth during which the mortality (or failure) rate decreases.
Berrut, Sylvie, Pouillard, Violette, Richmond, Peter, Roehner, Bertrand M.   +3 more
core  

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source