Results 91 to 100 of about 47,738 (314)

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Place des lipides dans l’alimentation du nourrisson

Oléagineux, Corps gras, Lipides, 2013
The rapid growth of the neonate requires a high intake of both energy and lipids. Fatty acids may play an important role in the brain development and in the etiology of several disorders in children and adults.
Guesnet Philippe, Ailhaud Gérard, Delplanque Bernadette, Alessandri Jean-Marc   +3 more
doaj   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Pregnancy‐related effect on elexacaftor, tezacaftor and ivacaftor pharmacokinetics in women with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Aim The number of pregnancies among women with cystic fibrosis (wwCF) has steadily increased over the past decade. However, the pharmacokinetics (PK) of elexacaftor–tezacaftor–ivacaftor (ETI) during gestation remains uncharacterized, despite its widespread use in this population.
Paulette Magnas, Naim Bouazza, Frantz Foissac, Saïk Urien, Léo Froelicher‐Bournaud, Gabrielle Lui, Victoria Guillemart, Nicolas Carlier, Jennifer Da Silva, Johanna Fesenbeckh, Reem Kanaan, Isabelle Honoré, Clémence Martin, Jean‐Marc Treluyer, Vassilis Tsatsaris, Pierre‐Régis Burgel, Sihem Benaboud   +16 more
wiley   +1 more source

THE NATURE OF THE REDUCING SUBSTANCE IN THE URINE OF INFANTS WITH NUTRITIONAL DISORDERS [PDF]

Archives of Pediatrics and Adolescent Medicine, 1921
The occurrence of a reducing substance in the urine of infants affected with gastro-enteric or nutritional disorders has long been recognized. Grosz1examined the urine of fifty breast fed infants and the urine of ten reduced Trommer's and Nylander's solutions. In no case did the urine ferment with yeast.
openaire   +1 more source

Immune development of children born from Caesarean section

, 2020
Several studies results have shown that mode of delivery affects the health of children, and recent studies showed that elective cesarean section (CS) is associated with aberrant short-term immune responses in the newborn baby and an increased risk of ...
Munasir, Zakiudin, Khoe, Levina Chandra
core   +1 more source

Differences in body composition between infants of South Asian and European ancestry: the London Mother and Baby Study. [PDF]

, 2012
BACKGROUND: South Asian children and adults have a more adipose body composition compared with those of European ancestry. This is thought to be related to their increased risk of metabolic disorders. However, little is known about how early in life such
Stanfield, KM, Chris Frost, Frost, C, Frost, Chris, Stanfield, Kristina M, Fewtrell, MS, Kristina M Stanfield, David A Leon, Leon, DA, Leon, David A, Wells, Jonathan C, Fewtrell, Mary S, Mary S Fewtrell, Wells, JC, Jonathan C Wells   +14 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

The Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study: Rationale and methods [PDF]

, 2014
The Alberta Pregnancy Outcomes and Nutrition (APrON) study is an ongoing prospective cohort study that recruits pregnant women early in pregnancy and, as of 2012, is following up their infants to 3 years of age.
Farmer, A., Gerald F. Giesbrecht, Kaplan, Bonnie J., Field, Catherine, Manca, Donna, Kooistra, L., Gagnon, L., O'Beirne, Maeve, Farmer, Anna, Giesbrecht, G.F., Cantell, M., Cantell, Marja, Manca, D.P., Lisa Gagnon, Goonewardene, Laki, Field, Catherine J., Bell, Rhonda C., APrON Study Team, O'Beirne, Maeve, McCargar, Linda, Kaplan, Bonnie, Dewey, D., David W. Johnston, Letourneau, Nicole, Nicole Letourneau, Bonnie J. Kaplan, Jonathan W. Martin, Marja Cantell, Misha Eliasziw, Bell, R.C., Francois P. Bernier, Libbe Kooistra, Martin, J.W., Bell, Rhonda, Victor J. Pop, Pop, Victor J., Singhal, N., Anna Farmer, Pop, V.J.M., Manca, Donna P., Martin, Jonathan W., Giesbrecht, Gerald, Casey, Linda M., Linda M. Casey, Laki Goonewardene, Kaplan, B.J., McCargar, L.J., Leung, Brenda M. Y., Casey, L.M., Johnston, David W., Deborah Dewey, Leung, Brenda, Donna P. Manca, Singhal, Nalini, Catherine J. Field, Rhonda C. Bell, Eliasziw, Misha, Bernier, Francois P., Nalini Singhal, O'Beirne, M., Linda J. McCargar, Johnston, D.W., Brenda M.Y. Leung, Johnston, David, Maeve O'Beirne, Leung, B.M., Martin, Jonathan, Letourneau, N., Dewey, Deborah, Casey, Linda, Field, C.J., Eliasziw, M., Giesbrecht, Gerald F., Gagnon, Lisa, Bernier, Francois, McCargar, Linda J., Bernier, F.P., Goonewardene, L., Kooistra, Libbe, Pop, Victor   +79 more
core   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source