Results 121 to 130 of about 2,076 (266)

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Socio-Emotional Skills and Physical Activity in Primary and Secondary Education Students. [PDF]

J Sch Health
Morcillo-Martínez A, Gómez-Barreto IM, Infantes-Paniagua Á, Fernández-Bustos JG.   +3 more
europepmc   +1 more source

Photoelectric‐Coupled Ferroelectric Heterojunctions for Ultrahigh NO2 Sensing With Polarization‐Memory‐Assisted Interfacial Modulation

Advanced Science, EarlyView.
This study demonstrates a Bi2WO6/SrBi2Ta2O9 heterojunction where light‐driven ferroelectric polarization reversal couples with persistent photoconductivity, enabling exclusive NO2 selective room‐temperature sensing. The device achieves a two‐order‐of‐magnitude sensitivity enhancement over an unpolarized device, a sub‐ppb detection limit, and robust ...
Liping Tan, Xuefeng Hu, Ming Zhou, Weiwei Qing, Along Li, Zilong Wang, Mudan Feng, Shuang Zhao, Xiaoliang Wang, Peipei Li, Yali Bi, Wei Zhang   +11 more
wiley   +1 more source

High inappropriate red blood cell transfusion rate despite low overall use: a real-world multicenter study in 43 Spanish hospitals. [PDF]

Front Med (Lausanne)
Tamayo-Velasco Á, Llau JV, Colomina MJ, de la Varga-Martínez O, Navarro-Pérez R, López-Herrero R, Almoguera-Fernández J, Alonso-Fernández M, Artiaga-Candia M, Becerra-Bolaños Á, Bugueño N, Casasempere-Sanus A, Contreras-López L, Heredia-Rodríguez M, de la Fuente-Graciani I, de la Rosa-Estadella M, de la Torre-Riveiro I, Del Val-Peciña E, Delgado-Martí C, Edo-Cebollada L, Fernández-Fernández R, Fernández-Rodríguez J, Ferrer-Gómez C, Giné-Servén M, González-Pereira A, Guereca-Gala A, Herrera-Soto A, Infantes-Morales ME, Marcos-Vidal JM, Illodo-Miramontes G, Martínez-López A, Martínez-Ruiz A, Martínez-Rafael B, Matute-González A, Pariente-Juste L, Pérez-González S, Gómez-Pesquera E, Renedo-Fernández A, Rodríguez-Álvarez AA, Sánchez-Rodríguez I, Del Aranzazú Rodríguez-Conesa M, Sánchez-González C, Tobar-Gonzalo C, Varela-Rodríguez L, Veloso-de Sousa R, Muñoz-Moreno MF, García-Sánchez JI, Rocha-García F, González-Montes P, Cid-Boo P, Escudero-Gómez G, Romero-García N, Cots A, Peñarrubia-Ponce MJ, Hornero R, Santamaría-Vázquez E, Poves-Álvarez R, Tamayo E, Varela-Duran M, Badenes R, DELPO Study Group.   +60 more
europepmc   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Advanced Digital Workflow for Lateral Orbitotomy in Orbital Dermoid Cysts: Integration of Point-of-Care Manufacturing and Intraoperative Navigation. [PDF]

J Clin Med
Ruiz-de-Leon G, Tousidonis M, Salmeron JI, Perez-Mañanes R, Alvarez-Mokthari S, Benito-Anguita M, Gonzalez-Moure B, Fernandez-Acosta D, Gomez de Los Infantes-Peña S, Rodriguez-Rodriguez M, Ortiz-Garcia C, Nieva-Pascual I, Cifuentes-Canorea P, Urcelay JL, Ochandiano S.   +14 more
europepmc   +1 more source

Expanded Hepatic Progenitor Cells Featured with Aggregation of α‐Synuclein Contribute to Pathologic Bile Duct Regeneration in Biliary Atresia

Advanced Science, EarlyView.
Expanded NCAM1+EpCAM+ hepatic progenitor cells in biliary atresia are characterized by aggregation of α‐synuclein. This pathological protein potentiates cellular susceptibility to GSH‐dependent redox dyshomeostasis, induces unstable biliary cell fate specification, and subsequently drives aberrant biliary regeneration.
Hua Xie, Mengyan Zhu, Zhongxian Zhu, Jiaqi Tang, Ruyi Zhang, Zequan Ding, Junzhi Li, Zhongluan Wu, Paul Kwong Hang Tam, Qianghu Wang, Vincent Chi Hang Lui, Yankai Xia, Weibing Tang   +12 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Acid-Catalyzed Dehydrative Nucleophilic Substitutions of 2,6-Di(hydroxymethyl) BODIPYs: A Platform for BODIPY Functionalization. [PDF]

Org Lett
Uriel C, Hernández A, Casado N, Bañuelos J, Duque-Redondo E, Infantes L, García-Moreno I, Gómez AM, López JC.   +8 more
europepmc   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source