Results 161 to 170 of about 147,297 (312)

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Subcutaneous and visceral adipose tissue lipidome in children reveals novel lipid species involved in obesity. [PDF]

J Physiol Biochem
Soria-Gondek A, Gonzalez-Riano C, Fernández-García P, Requena B, González L, Reyes-Farias M, Murillo M, Valls A, Real N, Villarroya F, Corrales P, Cereijo R, Herrero L, Barbas C, Sánchez-Infantes D.   +14 more
europepmc   +1 more source

The Emerging Parkinson's Disease Oxylipin‐Ome

Advanced Science, EarlyView.
ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley   +1 more source

Clinical performance of short implants vs. standard implants in edentulous patients. An umbrella review. [PDF]

Front Oral Health
Arbildo-Vega HI, Cruzado-Oliva FH, Infantes-Ruíz ED, Luján-Valencia SA, Meza-Málaga JM, Marroquín-Soto C, Coronel-Zubiate FT.   +6 more
europepmc   +1 more source

Tracking of [14C]Polystyrene Nanoplastics in Pregnant Mice

Advanced Science, EarlyView.
This study investigates [14C]polystyrene nanoplastic ([14C]PS) translocation in late‐stage pregnant mice after intranasal (0.5 mg of [14C]PS on GD12, GD14, and GD16, n = 6) and intravenous administration (1.5 mg of [14C]PS on GD16, n = 6). 14C‐radiolabel allows quantitative tracking of unmodified polystyrene nanoplastics.
Olga Khaybullina, Pallavi Sarkhel, Outi M. Keinänen   +2 more
wiley   +1 more source

Field evaluation of the P22 ELISA for diagnosis of caprine tuberculosis in an endemic area. [PDF]

Front Vet Sci
Velasco C, Ortega J, Alvarez J, Infantes Lorenzo JA, Moreno JC, Sanz C, Romero B, de Juan L, Dominguez L, Dominguez M, Moreno I, Roy A, Bezos J.   +12 more
europepmc   +1 more source

La vida del poeta novicio (Anónimo, 1605) [PDF]

, 2007
Infantes, V. (Víctor)
core  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

[Relationship among feeding behavior and cariogenic potential in early childhood. A review]. [PDF]

Rev Cient Odontol (Lima)
Guanoluisa-Barragán ND, Albán-Zambrano PL, Tinajero-Moscoso F, Molina-Jaramillo C, Luna-Chonata D.   +4 more
europepmc   +1 more source

Structural and Compositional Effects on the Scintillation Properties of Fast Emitting Metal‐Organic Frameworks

Advanced Science, EarlyView.
The crystalline structure, the atomic numbers of the constituent elementsand the size of MOF crystals each influence their photoluminescence and scintillation properties in distinct ways. Together, these factors provide valuable guidelines for designing systems with optimized performance and tunable timing characteristics, arising from the synergistic ...
Francesca Cova, Jacopo Perego, Biplab Joarder, Nobuhiro Yanai, Anna Vedda, Silvia Bracco, Angiolina Comotti, Angelo Monguzzi, Irene Villa   +8 more
wiley   +1 more source