Results 1 to 10 of about 1,226,813 (207)

Treatment efficacy for infantile epileptic spasms syndrome in children with trisomy 21 [PDF]

Frontiers in Pediatrics
BackgroundInfantile Epileptic Spasms Syndrome (IESS) is the most common epilepsy syndrome in children with trisomy 21. First-line standard treatments for IESS include adrenocorticotropic hormone (ACTH), oral corticosteroids, and vigabatrin.
Henry Chen, Henry Chen, Adam L. Numis, Adam L. Numis, Renée A. Shellhaas, John R. Mytinger, Debopam Samanta, Rani K. Singh, Rani K. Singh, Shaun A. Hussain, Danielle Takacs, Kelly G. Knupp, Li-Rong Shao, Carl E. Stafstrom   +13 more
doaj   +9 more sources

Infantile epileptic spasms syndrome: Mechanisms and therapeutic approaches [PDF]

Neurotherapeutics
Infantile epileptic spasms syndrome (IESS) is a developmental and. epileptic encephalopathy with unique clinical and electrographic features, including seizure semiology (spasms), numerous and diverse etiologies spanning structural, genetic and metabolic
Carl E. Stafstrom
doaj   +6 more sources

Infantile epileptic spasms syndrome: an etiologic study of 361 patients with infantile epileptic spasms syndrome [PDF]

Frontiers in Pediatrics
IntroductionInfantile Epileptic Spasms Syndrome (IESS) typically has a profound impact on the neurodevelopment of patients. The study on IESS indicates possible geographical variation in etiology and a lack of data from China.
Linghui Zhu, Linghui Zhu, Yuan Xia, Yuan Xia, Hao Ding, Tong Zhang, Jun Li, Baomin Li, Baomin Li   +8 more
doaj   +6 more sources

Clinical features of Infantile Epileptic Spasms Syndrome: a systematic review [PDF]

Orphanet Journal of Rare Diseases
Introduction Infantile Epileptic Spasms Syndrome (IESS) is a severe epilepsy in children between one month and two years of age. Urgent referral of possible IESS cases from pediatricians and family physicians who care for children to neurologists for ...
Xiao Meng, Danielle S. Takacs, Yashaswini Kelagere, Zihan Zhang, Sanjanaa Seshadri, Jiyeon Cha, Ming Li, Lei-Shih Chen   +7 more
doaj   +6 more sources

Infantile Epileptic Spasms Syndrome Complicating Mosaic Down‐Turner Syndrome: A Case Report [PDF]

Clinical Case Reports
Severe baseline developmental delays in complex genetic syndromes like Down‐Turner mosaicism can completely mask the psychomotor regression of Infantile Epileptic Spasms Syndrome (IESS).
Mohammad Shahrori, Khadeeja Nofal, Hasan H. Alkhawaja, Waed Mohsen, Ainaa A. Alzamari   +4 more
doaj   +3 more sources

Analysis of treatment outcome variations in infantile epileptic spasms syndrome [PDF]

Frontiers in Neurology
BackgroundTo explore the key factors influencing outcomes in children with infantile epileptic spasms syndrome (IESS) and to elucidate their interrelationships to provide insights for optimizing clinical practice.MethodsThis is a retrospective, single ...
Xue Gong, Xue Gong, Jing Gan, Jing Gan, Xiaoqian Wang, Jun Chen, Xueyi Rao, Jianjun Wang, Yajun Shen, Yajun Shen, Jia Zhang, Jia Zhang   +11 more
doaj   +5 more sources

Brazilian experts' consensus on the treatment of infantile epileptic spasm syndrome in infants

Arquivos de Neuro-Psiquiatria, 2023
Background Infantile epileptic spasms syndrome (IESS) is a rare but severe condition affecting children early and is usually secondary to an identifiable brain disorder.
Letícia Pereira de Brito Sampaio, Adélia Maria de Miranda Henriques-Souza, Mariana Ribeiro Marcondes da Silveira, Lisiane Seguti, Mara Lúcia Schmitz Ferreira Santos, Maria Augusta Montenegro, Sérgio Antoniuk, Maria Luíza Giraldes de Manreza   +7 more
doaj   +6 more sources

Case report: De novo variant of SETD1A causes infantile epileptic spasms syndrome

Frontiers in Neurology, 2023
Infantile epileptic spasms syndrome (IESS) is one of the most common epileptic encephalopathies of infancy, with typical clinical features defined by a triad of epileptic spasms, hypsarrhythmia, and developmental delay.
Mingping Lan, Yanjuan Wang, Sixiu Li, Lili Zhao, Ping Liu, Wenguang Hu   +5 more
doaj   +3 more sources

Infantile epileptic spasms syndrome: a cohort study of 88 children

Italian Journal of Pediatrics, 2023
Background This study aimed to investigate and analyze the risk factors for non-etiology-specific infantile spasms (IS) and unrelieved clinical symptoms after treatment.
Li-Hong Ren, Jing Zhang, Si-Xiu Li, Ping Liu, Hui Chen, Wenguang Hu   +5 more
doaj   +3 more sources

Development and validation of a machine learning model to predict prognostic outcomes in infantile epileptic spasms syndrome [PDF]

Frontiers in Pediatrics
ObjectiveTo develop and validate a machine learning (ML) model for predicting seizure outcomes in infants with infantile epileptic spasms syndrome (IESS).MethodsThis retrospective study enrolled pediatric patients diagnosed with infantile epileptic ...
Caoxue Zuo, Boen Xue, Xiaofeng Mu, Zhongqiang Cao, Huamin Zhou, Zhisheng Liu, Dan Sun   +6 more
doaj   +2 more sources