Results 21 to 30 of about 1,226,813 (207)
SinTransNet: an EEG-based deep learning framework for infantile epileptic spasms syndrome detection [PDF]
BMC Medical Informatics and Decision MakingInfantile Epileptic Spasms Syndrome (IESS) represents a severe form of developmental epileptic encephalopathy in infancy, characterized by clusters of spasms and hypsarrhythmia patterns on electroencephalogram (EEG), which often lead to long-term ...
Junyuan Feng +6 more
doaj +2 more sources
Integrated analysis of proteomics and metabolomics in infantile epileptic spasms syndrome. [PDF]
Sci RepInfantile Epileptic Spasms Syndrome (IESS) is a severe developmental epileptic encephalopathy that manifests in infancy, significantly impacting the health and quality of life of affected children. The treatment of IESS poses a significant challenge, primarily due to the incomplete understanding of its etiology and pathogenesis.
Chen J +5 more
europepmc +4 more sources
IESS-FusionNet: Physiologically Inspired EEG-EMG Fusion with Linear Recurrent Attention for Infantile Epileptic Spasms Syndrome Detection [PDF]
BioengineeringInfantile Epileptic Spasms Syndrome (IESS) is a devastating epileptic encephalopathy of infancy that carries a high risk of lifelong neurodevelopmental disability.
Junyuan Feng +6 more
doaj +2 more sources
Characterization of the plasma metabolomic profile in infantile epileptic spasms syndrome. [PDF]
Transl PediatrJiang L, Zhu M, Zhang Y, Yuan Z, Gao F.
europepmc +2 more sources
Epilepsy and BehaviorInfantile epileptic spasms syndrome (IESS) is a severe epileptic condition characterized by persistent uncontrolled seizures, with some children experiencing recurrent seizures despite multiple pharmacological therapies. The prognostic risk factorsassociated with IESS remain unclear. This study aimed to evaluate the factors influencing the efficacy and
Dandan Mao, Wenguang Hu
exaly +3 more sources
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023 Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei +4 more
wiley +1 more source
Long-term developmental outcome in infantile epileptic spasms syndrome after high-dose prednisolone and vigabatrin treatment. [PDF]
Epilepsia OpenAbstract Objective To evaluate long‐term developmental outcomes and identify independent predictors of favorable developmental outcomes at 3 years of age in children with infantile epileptic spasms syndrome (IESS) treated with a standardized stepwise vigabatrin and high‐dose prednisolone protocol.
Jang S +5 more
europepmc +2 more sources
Biochemical mechanisms in pathogenesis of infantile epileptic spasm syndrome
Seizure: European Journal of Epilepsy, 2023 The molecular mechanisms leading to infantile epileptic spasm syndrome (IESS) remain obscure. The only common factor seems to be that the spasms are restricted to a limited period of infancy, during a certain maturational state. Here the current literature regarding the biochemical mechanisms of brain maturation in IESS is reviewed, and various ...
openaire +3 more sources
Frontiers in Genetics, 2022 Objective: To analyze the clinical feature, treatment, and prognosis of epileptic spasms (ES) in vitamin B6–dependent epilepsy, including patients with pyridoxine-dependent epilepsy (PDE) caused by ALDH7A1 mutation, pyridox(am)ine-5′-phosphate oxidase ...
Xianru Jiao +4 more
doaj +1 more source
BMC Neurology, 2022 Background Epileptic spasms are a devastating form of early infantile epileptic encephalopathy (EIEE) with various etiologies. Early diagnosis and a shorter lead time to treatment are crucial to stop the seizures and optimize the neurodevelopmental ...
Kullasate Sakpichaisakul +6 more
doaj +1 more source