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The underlying etiology of infantile spasms (West syndrome): Information from the International Collaborative Infantile Spasms Study (ICISS)

open access: bronze, 2019
John Osborne   +16 more
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Infantile spasms

Current Treatment Options in Neurology, 2001
Infantile spasms is a catastrophic form of epilepsy found only in infants and young toddlers, with the peak incidence between 4 - 7 months of age. Estimated prevalence is 1 in 2000 - 6000 live births. There are many causes of infantile spasms, including tuberous sclerosis, hypoxic-ischaemic injury, congenital infectious diseases, inborn errors of ...
M, Wong, E, Trevathan
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Infantile Spasms

Neurologic Clinics, 1990
Infantile spasms are a seizure disorder in young infants with diverse etiologies, suggesting that they arise from any disturbance of central nervous system function during susceptible periods of development. The prognosis for normal intellectual and neurologic development parallels that of the underlying etiology.
G B, Bobele, J B, Bodensteiner
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Vigabatrin for infantile spasms [PDF]

open access: possiblePediatric Neurology, 2002
We reviewed 20 infants receiving vigabatrin for infantile spasms. Patients were not enrolled in a formal study. All families obtained the medication abroad. Age at initiation of vigabatrin ranged from 1 to 48 months; nine infants had received prior treatment with various antiepileptic medications. Patients were begun on the lowest practical dose of 125-
Wendy G. Mitchell, Namrata S. Shah
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Treatment of infantile spasms

Cochrane Database of Systematic Reviews, 2008
Infantile spasms (West's Syndrome) is a syndrome which includes a peculiar type of epileptic seizure, the spasms, and an electroencephalogram (EEG) abnormality often called hypsarrhythmia. Psychomotor retardation is frequently found at follow up. Approximately two thirds of affected infants will have a detectable underlying neurological abnormality ...
John P. Osborne   +2 more
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Infantile Spasms

The Neurologist, 2010
Infantile spasms (West syndrome) is an epilepsy condition affecting 1 in 2000 infants. Perhaps no more worrisome neurologic disorder exists because of its frequent association with delayed development and cognition at such a young age. Despite its existence in the literature since 1841, proven therapies are limited because of efficacy, tolerability, at
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The management of infantile spasms

Archives of Disease in Childhood, 2008
Infantile spasms (IS) is the most frequent epilepsy syndrome in infancy. Although the consensus triad of spasms in clusters with hypsarrhythmia adversely affecting psychomotor development1 seems quite straightforward, the great variability of each component is a challenge not only to the clinician involved in management of the condition but also to the
Rima Nabbout   +2 more
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Symptomatology of infantile spasms

Brain and Development, 2001
Epileptic spasms in West syndrome consist of a brief phasic contraction followed by a gradually relaxing tonic component, associated with typical ictal electroencephalographic (EEG) patterns. Three different EEG patterns are associated with a clinical spasm: fast wave bursts, high voltage slow waves (HVS), and desynchronization, occurring in this order.
Akihisa Okumura   +2 more
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Infantile spasms

Current Opinion in Neurology, 1995
The recent intense focus of attention on further characterization and management of infantile spasms is due, in part, to the resistant nature of these seizures and the frequently poor cognitive outcome, even when the seizures are controlled. Technological advances have increased our ability to diagnose specific brain disorders associated with infantile
openaire   +2 more sources

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