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2002
Infantile spasms (West's Syndrome) is a syndrome which includes a peculiar type of epileptic seizure, usually hypsarrhythmia and in the majority of people, psychomotor retardation. It remains poorly understood and despite modern imaging techniques an underlying cause is often not found. Little is known about their pathophysiological basis and treatment
E, Hancock, J P, Osborne, P, Milner
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Infantile spasms (West's Syndrome) is a syndrome which includes a peculiar type of epileptic seizure, usually hypsarrhythmia and in the majority of people, psychomotor retardation. It remains poorly understood and despite modern imaging techniques an underlying cause is often not found. Little is known about their pathophysiological basis and treatment
E, Hancock, J P, Osborne, P, Milner
openaire +3 more sources
JAMA, 1967
SINCE West 1 vividly described the syndrome of infantile spasms with progressive mental deterioration 125 years ago, the condition has been known under a variety of names, such as nodding spasms, salaam seizures, jack-knife seizures, "lightning majors," and massive myoclonic epilepsy.
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SINCE West 1 vividly described the syndrome of infantile spasms with progressive mental deterioration 125 years ago, the condition has been known under a variety of names, such as nodding spasms, salaam seizures, jack-knife seizures, "lightning majors," and massive myoclonic epilepsy.
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Pathophysiology of Infantile Spasms
2002Infantile spasms--seen in West's Syndrome--are often associated with cortical abnormalities. The spasms themselves, however, appear to be generated subcortically. Dr. Chugani reviews the clinical data related to the pathophysiology of infantile spasms and proposes a hypothesis which involves both cortical and subcortical mechanisms.
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INFANTILE SPASMS AND HYPSARRHYTHMIA
The Lancet, 1959B D, BOWER, P M, JEAVONS
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