Results 71 to 80 of about 9,688 (217)

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

Ocorrência de doenças infecciosas em gatos do Planalto Catarinense

Revista de Ciências Agroveterinárias, 2018
Os gatos estão entre os animais de estimação mais comuns no mundo inteiro e é cada vez mais estreito o seu convívio com os humanos, o que torna os estudos epidemiológicos relativos às doenças que afetam essa espécie de grande importância.
Giovana Biezus, Renata Assis Casagrande, Paulo Eduardo Ferian, Marília Gabriela Luciani, Juliana Regina de Souza, Suelen Dal Pozo, Cristiane Borges Vargas, Thierry Grima de Cristo   +7 more
doaj   +1 more source

Chain‐Length Regulation by WzzE Is Necessary for, but Genetically Separable From, Cyclic Enterobacterial Common Antigen Synthesis

Molecular Microbiology, EarlyView.
Here, we demonstrate that polysaccharide chain length regulation plays a distinct role in enabling formation of a cyclic molecule important for the bacterial cell surface. However, this function is necessary, but not sufficient for the cyclic molecule's biosynthesis.
Joseph F. Carr, Yohannes H. Rezenom, Jennifer S. Rudolf, Daniel J. Warzecha, Angela M. Mitchell   +4 more
wiley   +1 more source

Manejo del dolor y procesos infecciosos en urgencias endodónticas

, 2023
PDFEl dolor es la respuesta del organismo a la invasión o lesión tisular. Por ello, los profesionales necesitan conocer y aumentar sus conocimientos sobre las causas, tratamientos y el manejo clínico y farmacológico del dolor y procesos infecciosos en
Carmona Mendía, Marlon Adrián
core  

A Single‐Nucleotide Substitution Generates a de Novo Promoter That Activates a Latent Metabolic Bypass in Escherichia coli

Molecular Microbiology, EarlyView.
A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo, Qi Zou, Jilong Qin, Makrina Totsika, Yaoqin Hong, John E. Cronan   +5 more
wiley   +1 more source

Human Rhinovirus A16 Infection of Mast Cells Promotes T2 and Non‐T2 Immune Responses That Are Modulated by the Airway Epithelium

Allergy, EarlyView.
Ying Lai, Ryan C. Murphy, Matthew Liu, Maciej W. Czarnecki, Dane Grosvenor, Kimberly A. Dill‐McFarland, Adrian M. Piliponsky, Jason S. Debley, Matthew C. Altman, Teal S. Hallstrand   +9 more
wiley   +1 more source

User and Provider Experiences with a Digital Health Family Planning Counseling Tool for Women Living with HIV in Kenya

Studies in Family Planning, EarlyView.
Abstract Women living with HIV(WLHIV) have diverse and complex reproductive health needs that require patient‐centered, informed decision‐making. Digital tools to support reproductive life planning may improve reproductive health counseling and outcomes for these women.
Agnes Karingo Karume, Alison L. Drake, June Moraa, Celestine Atieno, Nancy Ngumbau, Aparna Seth, Kristin Beima‐Sofie, John Kinuthia, Jennifer A. Unger   +8 more
wiley   +1 more source

A novel JAK1 variant in chronic eosinophilic leukaemia with response to benralizumab

British Journal of Haematology, EarlyView.
Isabel C. Vallecillo‐Viejo, Michael D. Claiborne, Charles F. Anderson, Samantha Shafer, Alan Saven, Bryce A. Seifert, Morgan Similuk, Magdalena Walkiewicz, Irina Maric, Pia R. Crespo, Lori Broderick, Andrew A. White, Amy D. Klion   +12 more
wiley   +1 more source

Retinol, Carotenoid, and Tocopherol Intake and Status, and the Risk of Islet Autoimmunity and Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Aims To study the associations of dietary intake of A and E vitamins, as well as plasma retinols, carotenoids, and tocopherols in relation to development of islet autoimmunity and progression to T1D. Materials and Methods The Environmental Determinants of Diabetes in the Young (TEDDY) Study followed 7659 newborns with genetic susceptibility to
Leena Hakola, Joanna L. Clasen, Ulla Uusitalo, Carin Andrén Aronsson, Sandra Hummel, Markus Mattila, Sari Niinistö, Jorma Toppari, Anette‐G. Ziegler, William A. Hagopian, Beena Akolkar, Marian J. Rewers, Richard A. McIndoe, Åke Lernmark, Jeffrey P. Krischer, Jill M. Norris, Iris Erlund, Suvi M. Virtanen, the TEDDY Study Group   +18 more
wiley   +1 more source

Marcadores infecciosos transmisibles y su relación con variables demográficas en donantes - Hospital Nacional Hipólito Unanue [PDF]

, 2018
Objetivos: En este estudio se determinó la prevalencia de los marcadores infecciosos transmisibles y sus variables demográficas en Donantes del Banco de Sangre del Hospital Nacional Hipólito Unanue del 2014 al 2016.
Llactahuamán Sulca, Carmen Yovana, Rojas Callo, Liset   +1 more
core