Results 91 to 100 of about 8,269,565 (363)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Burden of Clostridium difficile Infection in the United States

New England Journal of Medicine, 2015
background The magnitude and scope of Clostridium difficile infection in the United States continue to evolve. methods In 2011, we performed active population- and laboratory-based surveillance across 10 geographic areas in the United States to identify ...
Fernanda C. Lessa, Yi Mu, Wendy M. Bamberg, Z. Beldavs, G. Dumyati, John R. Dunn, M. Farley, S. Holzbauer, James I. Meek, Erin C. Phipps, Lucy E. Wilson, L. Winston, Jessica a. Cohen, B. Limbago, S. Fridkin, D. Gerding, L. Clifford Mcdonald   +16 more
semanticscholar   +1 more source

Comparison of two methods for attributing length of hospital stay to healthcare-acquired infection

, 2008
The development of models of the cost-effectiveness of infection control programs must be informed by valid estimates of the extra length of hospital stay due to healthcare-acquired infection (HAI).
Whitby, Michael, Faddy, Malcolm J., Graves, Nicholas, Tong, Edward   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Monocyte recruitment during infection and inflammation

Nature reviews. Immunology, 2011
Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave the bloodstream and migrate into tissues where, following conditioning by
C. Shi, E. Pamer
semanticscholar   +1 more source

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

Science, 2020
Immunity from reinfection One of the many open questions about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is whether an individual who has cleared the virus can be infected a second time and get sick. Chandrashekar et al.
A. Chandrashekar, Jinyan Liu, Amanda J. Martinot, K. McMahan, N. Mercado, Lauren Peter, Lisa H. Tostanoski, Jingyou Yu, Z. Maliga, M. Nekorchuk, K. Busman-Sahay, Margaret Terry, Linda M. Wrijil, Sarah Ducat, David R. Martinez, C. Atyeo, S. Fischinger, J. Burke, Matthew D. Slein, Laurent Pessaint, Alex Van Ry, J. Greenhouse, Tammy Taylor, Kelvin Blade, Anthony Cook, Brad Finneyfrock, Renita Brown, Elyse Teow, Jason Velasco, R. Zahn, F. Wegmann, P. Abbink, E. Bondzie, Gabriel Dagotto, M. Gebre, Xuan He, C. Jacob-Dolan, N. Kordana, Zhenfeng Li, M. Lifton, S. Mahrokhian, Lori F. Maxfield, Ramya Nityanandam, Joseph P. Nkolola, A. Schmidt, Andrew D. Miller, R. Baric, G. Alter, P. Sorger, J. Estes, H. Andersen, M. Lewis, D. Barouch   +52 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity

, 2011
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman, Malte Heeg, John, Mina, Pfafferott, K, James, Ian, Ulsenheimer, Axel, Helmut M. Diepolder, Lucas, A.D., Silvana Gaudieri, Heeg, M, Rauch, A, Ian James, John, M., Andri Rauch, Klenerman, P., James, I, Simon Mallal, Diepolder, HM, Heeg, Malte, John, M, Mallal, Simon, Lucas, Andrew, Nolan, D., Lucas, M., Heeg, M., Michaela Lucas, Diepolder, H.M., Mallal, S., Gaudieri, S, Lucas, M, Gaudieri, S., Nolan, David, Ulsenheimer, A, Lucas, A, David Nolan, Klenerman, Paul, Diepolder, Helmut M., Pfafferott, K., Klenerman, P, Rauch, A., Ulsenheimer, A., Pfafferott, Katja, Lucas, Michaela, Katja Pfafferott, Andrew Lucas, Rauch, Andri, Diepolder, Helmut M, Axel Ulsenheimer, Mina John, Helmut M Diepolder, Nolan, D, Mallal, S, James, I., Gaudieri, Silvana   +53 more
core   +1 more source

In silico genomic surveillance by CoVerage predicts and characterizes SARS-CoV-2 variants of interest

Nature Communications
Rapidly evolving viral pathogens such as SARS-CoV-2 continuously accumulate amino acid changes, some of which affect transmissibility, virulence or improve the virus’ ability to escape host immunity.
Katrina Norwood, Zhi-Luo Deng, Susanne Reimering, Gary Robertson, Mohammad-Hadi Foroughmand-Araabi, Sama Goliaei, Martin Hölzer, Frank Klawonn, Alice C. McHardy   +8 more
doaj   +1 more source