Results 101 to 110 of about 7,548,706 (340)

Presymptomatic, asymptomatic and post-symptomatic transmission of SARS-CoV-2: joint British Infection Association (BIA), Healthcare Infection Society (HIS), Infection Prevention Society (IPS) and Royal College of Pathologists (RCPath) guidance

BMC Infectious Diseases, 2022
Moira A. Mugglestone, Natasha V. Ratnaraja, Aggie Bak, Jasmin Islam, Jennie A. Wilson, Jennifer Bostock, Samuel E. Moses, James R. Price, Michael Weinbren, Heather P. Loveday, Lucy Rivett, Simon M. Stoneham, A. Peter R. Wilson   +12 more
doaj   +1 more source

O-GlcNAcylation stabilizes the autophagy-initiating kinase ULK1 by inhibiting chaperone-mediated autophagy upon HPV infection

, 2022
Yingxin Shi, Sheng Yan, Guang-Can Shao, Jinglong Wang, Yong‐Ping Jian, Бо Лю, Yanqiu Yuan, Ke Qin, Shanshan Nai, Xiahe Huang, Yingchun Wang, Zhenghui Chen, Xing Chen, Meng‐Qiu Dong, Yiqun Geng, Zhi‐Xiang Xu, Jing Li   +16 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases

Nature Communications
Many CRISPR-Cas immune systems generate guide (g)RNAs using trans-activating CRISPR RNAs (tracrRNAs). Recent work revealed that Cas9 tracrRNAs could be reprogrammed to convert any RNA-of-interest into a gRNA, linking the RNA’s presence to Cas9-mediated ...
Chunlei Jiao, Natalia L. Peeck, Jiaqi Yu, Mohammad Ghaem Maghami, Sarah Kono, Daphne Collias, Sandra L. Martinez Diaz, Rachael Larose, Chase L. Beisel   +8 more
doaj   +1 more source

Helicobacter pylori infection

Nature Reviews Disease Primers, 2023
P. Malfertheiner, M. C. Camargo, E. El-Omar, Jyh-Ming Liou, R. Peek, C. Schulz, Stella I Smith, S. Suerbaum   +7 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Adherence to national recommendations for the control of multidrug-resistant microorganisms in Swiss acute care hospitals – an updated national survey

Antimicrobial Resistance and Infection Control
Summary Background Screening patients at risk of multidrug-resistant organism (MDRO) carriage is a cornerstone of infection prevention and control to identify carriers and prevent transmission. In 2021, the Swiss Centre for Infection Prevention Swissnoso
Andrea C. Büchler, Aliki Metsini, Niccolò Buetti, Aline Wolfensberger, Simon Gottwalt, Carlo Balmelli, Gaud Catho, Philipp Jent, Hugo Sax, Laurence Senn, Andreas F. Widmer, Matthias Schlegel, Sarah Tschudin-Sutter, Stephan Harbarth, Danielle Vuichard-Gysin, for Swissnoso   +15 more
doaj   +1 more source

Effects of vitamins A, C, and D and zinc on urinary tract infections

, 2023
Peng Gao, Weijing Liang, Haimei Li, Lijia Guan, Qian Zhao, Dan Li   +5 more
openalex   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Early Steps in Herpes Simplex Virus Infection Blocked by a Proteasome Inhibitor [PDF]

, 2019
Seth M. Schneider, Suzanne M. Pritchard, George A. Wudiri, Chasity E. Trammell, Anthony V. Nicola   +4 more
openalex   +1 more source