Results 131 to 140 of about 5,236,282 (261)
Early detection of Coxiella burnetii growth on axenic media using scanning electron microscopy
Microbiology SpectrumCoxiella burnetii, the causative agent of Q fever, is a highly infectious obligate intracellular bacterium. In consequence, cultivating this pathogen was fastidious and resource-consuming, requiring 3 weeks for isolation in cell culture. In recent years,
Asmae El Moutawakil +5 more
doaj +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Clinical Significance and Functional Insights of Tesmin in Hepatocellular Carcinoma
Genetics ResearchBackground. Tesmin, a 60 kDa protein encoded by the metallothionein-like 5 (MTL5) gene, plays a vital role in spermatogenesis and oogenesis. Recent research has unveiled its potential involvement in malignancies, although its impact on HCC remains poorly
Lijun Cao, Lin Zhang, Siyu Liu, Xue Wang
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Infection control in healthcare personnel : infrastructure and routine practices for occupational infection prevention and control services [PDF]
Updated: October 2019This document, Infection Control in Healthcare Personnel: Infrastructure and Routine Practices for Occupational Infection Prevention and Control Services, is an update of four sections of Part I of the Guideline for infection control
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Evolution of HIV-1 subtype C immune responses during acute and chronic HIV infection [PDF]
, 2011 The aim of this study was to compare the magnitude and breadth of HIV-specific T cell responses to HIV Gag and Nef mounted during acute HIV infection with those that emerged during chronic infection and to investigate the association of these responses ...
Gamieldien, Hoyam
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Infection and Drug ResistanceJinchuan Shi,1 Wenhui Zhang,1,2 Jie Han,1,2 Zhongdong Zhang,1 Dingyan Yan,1,2 Rongrong Zheng,1 Feng Li,1 Yi Wang1,3 1Department of Infection, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Hangzhou, 310023, People’s Republic of ...
Shi J +7 more
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source