Results 171 to 180 of about 5,236,282 (261)

<i>Mycobacterium tuberculosis</i> suppresses protective Th17 responses during infection. [PDF]

Elife
Zilinskas A, Balakhmet A, Fox D, Ni HM, Agudelo C, Samani H, Stanley SA.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Clinical Characteristics of Patients With AIDS and Talaromyces marneffei Infection of the Central Nervous System: A Retrospective Observation Study

AIDS Research and Treatment
Yunmei Li, Jinhong He, Xiangxi He, Yinshuang Peng, Xingxing Luo, Xiaoxin Xie, Yanhua Fu, Hai Long   +7 more
doaj   +1 more source

High <i>ex vivo</i> recombination rate of African swine fever virus in porcine alveolar macrophages. [PDF]

Vet Q
Mészáros I, Olasz F, Miklós I, Göltl E, Oláh B, Zádori Z.   +5 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Interferon-λ signaling to maternal dendritic cells protects against congenital Zika virus infection. [PDF]

Sci Adv
Dedloff MR, Reinhardt TR, Ropp TF, Rivera-Cardona J, Robles CR, Casazza RL, Ezzell JA, Itano MS, Lazear HM.   +8 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Hospital mortality and positive blood culture with Difficult-to threat (DTR), Marseille, France

Journal of Infection and Public Health, 2020
O. Diallo, S. Baron, M. Jimeno, C. Abat, G. Dubourg, H. Chaudet, D. Raoult, J. Rolain   +7 more
doaj   +1 more source