Results 161 to 170 of about 8,269,565 (363)
Frontiers in ImmunologyBackgroundBloodstream infections (BSI) are life-threatening conditions initiated by pathogens entering the circulation, with Staphylococcus aureus among the most lethal causative agents.
Obiageli V. Nwofor +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Antibody-dependent enhancement of HIV-1 infection.
, 2007 Antibody-dependent enhancement (ADE) is the process by which virus-specific antibodies enhance entry or replication of a virus, leading to increased infection and the potential to exacerbate disease progression or severity. In terms of HIV infection, ADE
Willey, S., Willey, Suzanne
core
Infection and Drug ResistanceJinchuan Shi,1 Wenhui Zhang,1,2 Jie Han,1,2 Zhongdong Zhang,1 Dingyan Yan,1,2 Rongrong Zheng,1 Feng Li,1 Yi Wang1,3 1Department of Infection, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Hangzhou, 310023, People’s Republic of ...
Shi J +7 more
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
CHARACTERISING FACTORS PREDICTIVE OF INFECTION IN SEVERELY INJURED PATIENTS [PDF]
, 2015 Infection after trauma complicates the patients clinical course. Infection leads to longer critical care and hospital stays, has been associated with increased mortality rates and places considerable cost pressures on health economies.
Cole, Elaine
core
, 2015 Introduction: There is limited data in the literature about brucellosis related to an intracellular pathogen and anti-tumor necrosis factor alpha (anti-TNF?) medication.
Ergin, Ç. +6 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source