Results 71 to 80 of about 7,548,706 (340)

Assessing the Impact of Reduced Travel on Exportation Dynamics of Novel Coronavirus Infection (COVID-19) [PDF]

, 2020
Asami Anzai, T. Kobayashi, Natalie M. Linton, Ryo Kinoshita, Katsuma Hayashi, Ayako Suzuki, Yichi Yang, Sung-mok Jung, Takeshi Miyama, Andrei R. Akhmetzhanov, Hiroshi Nishiura   +10 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

In silico genomic surveillance by CoVerage predicts and characterizes SARS-CoV-2 variants of interest

Nature Communications
Rapidly evolving viral pathogens such as SARS-CoV-2 continuously accumulate amino acid changes, some of which affect transmissibility, virulence or improve the virus’ ability to escape host immunity.
Katrina Norwood, Zhi-Luo Deng, Susanne Reimering, Gary Robertson, Mohammad-Hadi Foroughmand-Araabi, Sama Goliaei, Martin Hölzer, Frank Klawonn, Alice C. McHardy   +8 more
doaj   +1 more source

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

Nature Medicine, 2021
D. Khoury, D. Cromer, A. Reynaldi, T. Schlub, A. Wheatley, J. Juno, K. Subbarao, S. Kent, J. Triccas, M. Davenport   +9 more
semanticscholar   +1 more source

Burden of Clostridium difficile infection in the United States.

New England Journal of Medicine, 2015
BACKGROUND The magnitude and scope of Clostridium difficile infection in the United States continue to evolve. METHODS In 2011, we performed active population- and laboratory-based surveillance across 10 geographic areas in the United States to ...
F. Lessa, Yi Mu, Wendy M. Bamberg, Z. Beldavs, G. Dumyati, J. Dunn, M. Farley, S. Holzbauer, J. Meek, Erin C. Phipps, L. Wilson, L. Winston, Jessica a. Cohen, B. Limbago, S. Fridkin, D. Gerding, L. McDonald   +16 more
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk [PDF]

, 2020
Yahui Guo, Shinji Kasahara, Anupam Jhingran, Nicholas L. Tosini, Bing Zhai, Mariano A. Aufiero, K. Mills, Mergim Gjonbalaj, Vanessa Espinosa, Amariliz Rivera, Andrew D. Luster, Tobias M. Hohl   +11 more
openalex   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source