Results 31 to 40 of about 3,746,616 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ensuring Accuracy: Making the Case for Inter-rater Reliability in Hospital Acquired Infection Surveillance

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Infection preventionists (Ips) have self-reported surveillance as the most time-consuming job task (1,2). APIC’s MegaSurvey 2020 reported that 60% of Ips consider themselves proficient or expert within this competency domain (2).
Kelly Holmes, Mishga Moinuddin, Sandi Steinfeld   +2 more
doaj   +1 more source

Peripheral venous catheter-related bloodstream infection is associated with severe complications and potential death: a retrospective observational study

BMC Infectious Diseases, 2017
Background The purpose of this study was to identify the clinical characteristics and outcomes of peripheral vascular catheter-related bloodstream infections (PVC-BSIs) and determine the risk of severe complications or death.
Akihiro Sato, Itaru Nakamura, Hiroaki Fujita, Ayaka Tsukimori, Takehito Kobayashi, Shinji Fukushima, Takeshi Fujii, Tetsuya Matsumoto   +7 more
doaj   +1 more source

Outbreak investigation of Serratia marcescens neurosurgical site infections associated with a contaminated shaving razors

Antimicrobial Resistance and Infection Control, 2020
Background Surgical site infection (SSI) is the most common healthcare-associated infection. We report an outbreak of neurosurgical site infections caused by Serratia marcescens after craniotomy in a tertiary care hospital.
Eun Jin Kim, Wan Beom Park, Jung-Ki Yoon, Won-Sang Cho, Su Jung Kim, Young Rok Oh, Kang Il Jun, Chang Kyung Kang, Pyeong Gyun Choe, Jong-Il Kim, Eun Hwa Choi, Myoung Don Oh, Nam Joong Kim   +12 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Adherence to national recommendations for the control of multidrug-resistant microorganisms in Swiss acute care hospitals – an updated national survey

Antimicrobial Resistance and Infection Control
Summary Background Screening patients at risk of multidrug-resistant organism (MDRO) carriage is a cornerstone of infection prevention and control to identify carriers and prevent transmission. In 2021, the Swiss Centre for Infection Prevention Swissnoso
Andrea C. Büchler, Aliki Metsini, Niccolò Buetti, Aline Wolfensberger, Simon Gottwalt, Carlo Balmelli, Gaud Catho, Philipp Jent, Hugo Sax, Laurence Senn, Andreas F. Widmer, Matthias Schlegel, Sarah Tschudin-Sutter, Stephan Harbarth, Danielle Vuichard-Gysin, for Swissnoso   +15 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A scoping review of published reports of the infection prevention and control assessment framework: a comparison to the findings of the global report on infection prevention and control [PDF]

Background: The World Health Organization (WHO) published the Global Report on Infection Prevention and Control (IPC) in 2022, highlighting both achievements and areas for improvement in IPC practices globally.
Zimmerman, Peta-Anne, Mason, Matt
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source