Results 51 to 60 of about 3,746,616 (308)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Hepatitis C virus infection epidemiology among people who inject drugs in Europe: a systematic review of data for scaling up treatment and prevention. [PDF]

, 2014
BACKGROUND: People who inject drugs (PWID) are a key population affected by hepatitis C virus (HCV). Treatment options are improving and may enhance prevention; however access for PWID may be poor.
Mcdonald, B, Hope, V, Basso, M, Eramova, I, Abel-Ollo, Katri, Sperle, Ida, Michot, I, Sperle, Ide, Hatzakis Angelos, Van Houdt, Sabine, Ferri, Marica, Griffiths, Paul, Lazarus Jeffrey V., Vickerman Peter, Částková, Jitka, Rosińska, Magdalena, Tarjan, A, Maria Prins, Aleixandre, Noelia Llorens, Vivian D. Hope (605401), Klavs, I, Fouchard, Jan, Brummer-Korvenkontio, Henrikki, Grady, Bart, Matheï, Catharina, Brummer-Korvenkontio, H, Berglund, T, Kantzanou Maria, Ncube, F, Lopes, Sofia, Eramova, Irina, Struzik, M, Catharina Matheï (605402), Kostrikis, L, Abagiu, Adrian Octavian, Vickerman, P, Fouchard, J, Goldberg, David, Jauffret-Roustide, Marie, Rehak, V, Fotsiou, Nasia, Mravcik, V, Caplinskiene, Irma, Folch, Cinta, Fotiou, A, Melillo, Jackie, Kustec, T, Hobstová, Jiřina, Lazarus, JV, Lazarus, Jeffrey V., Bravo, Maria Jose, Tarján, Anna, Mathei, C, Brisacier, A-C, Prins, Maria, Demanuele, Carlo Olivari, Isabelle Giraudon, EK, Wiessing, Lucas, Fotiou, Anastasios, Martins, Helena Cortes, Nechanska, B, Hope, Vivian D., Hobstova, J, Marica Ferri (605396), Grady, B, Wiessing, L, Bollaerts, Kaat, Giraudon, Isabelle, Rosinska, M, Fotsiou, N, Bogdanova, V, Struzik, Marta, Hutchinson, Sharon, Cullen, Katelyn J., Wiessing Lucas, Ruta, S, Kustec, Tanja, Catharina Matheï, Vilar, G, Hutchinson, S, Bogdanova, Violeta, Croes, Esther, Op De Coul, Eline, Ida Sperle (605399), Origer, A, Michot, Isabelle, Klavs, Irena, Palladino, C, Angelos Hatzakis (146074), Hatzakis, Angelos, Peter Vickerman, Nesheva, E, Katelyn J Cullen, Lazarus, Jeffrey V, Camilleri, M, Tallo, Tatjana, Brisacier, Anne Claire, Hope Vivian D., Martins, HC, Bollaerts, K, Hope, Vivian D, Goldberg, D, Cullen, KJ, Prins, M, Maria Prins (339491), Gómez, Rosario Sendino, Platt, Lucy, Kantzanou, Maria, EMCDDA DRID group, Hotho, Daphne, Van Houdt, S, Martins, M, Cullen, Katelyn J, Low, Andrea, Thornton, Lelia, Hutchinson, Sharon; id_orcid, Prins Maria, Palladino, Claudia, Tefanova, Valentina, Resende, Maria Emília, Resende, E, Marica Ferri, Kalamara, Eleni, Galvin, B, Karnite, A, Gomez, RS, Zimmermann, R, Ferri, M, Strandberg, J, Bart Grady (605397), Tallo, T, Busch, M, Folch, C, Gazdag, Gábor, Strandberg, Joakim, Jeffrey V Lazarus, Maria Kantzanou (605398), Jeffrey V. Lazarus (250583), Grady Bart, Abel-Ollo, K, Mcdonald, Bethan, Nechanská, Blanka, Lopes, S, Castkova, J, Maria Kantzanou, Ferri Marica, Kopilovic, B, Ruta, Simona, Vivian D. Hope, Gazdag, G, Duran, Domingos, Galvin, Brian, Groshkova, Teodora, Arama, V, Caplinskiene, I, Jeffrey V. Lazarus, Ida Sperle, Kantzanou, M, Croes, E, Garavan, C, Busch, Martin, Cruciani, Mario, Berglund, Torsten, Origer, Alain, Vilar, Graça, Melillo, J, Kopilovic, Boris, Řehák, Vratislav, Hope, VD, Cullen Katelyn J., Low, A, Matheï Catharina, Martins, Mário, Vicente, J, Angelos Hatzakis, Sperle, I, Nesheva, Elmira, Mravčík, Viktor, Platt, L, Demanuele, CO, Ncube, Fortune, Cruciani, M, Zimmermann, Ruth, Tefanova, V, Lucas Wiessing (483360), Lucas Wiessing, Thornton, L, Aleixandre, NL, Groshkova, T, Arama, Victoria, Bravo, MJ, Katelyn J. Cullen (605400), Jauffret-Roustide, M, Abagiu, AO, Sperle Ida, Op de Coul, E, Vivian D Hope, Duran, D, Kostrikis, Leontios, Karnite, Anda, Hotho, D, Yury E. Khudyakov, Bart Grady, Vickerman, Peter, BASSO, MONICA, Griffiths, P, Vicente, Julian, Peter Vickerman (210007), Katelyn J. Cullen, Hatzakis, A, Camilleri, Moses   +210 more
core   +1 more source

Results from the second Scottish national prevalence survey: the changing epidemiology of healthcare-associated infection in Scotland [PDF]

, 2012
Healthcare-associated infections (HAIs) are a recognized public health problem worldwide. Point prevalence surveys (PPSs) can be used to measure the burden of all HAI types.
Fleming, S., Reilly, Jacqui; id_orcid, Hewitt, D., Williams, C., Reilly, J., Robertson, C., Lawder, R., Malcolm, W., Malcolm, William, Fleming, S, Cairns, Shona, Robertson, Chris, Nathwani, D., Cairns, S., Nathwani, Dilip   +14 more
core   +3 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Case validation of bloodstream infections with an antibiotic-resistant organism

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Bloodstream infections (BSIs) are an important cause of morbidity and mortality in severely ill patients, contributing to increased length of hospital stay and higher cost of care. Alberta Health Services Infection Prevention and Control (IPC)
Jennifer Ellison, Blanda Chow, Andrea Howatt, Logan Armstrong, Ted Pfister, Zhe Lu, Kathryn Bush   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Preventing HIV infection [PDF]

BMJ, 2005
In 2002 the prevailing view was that preventive strategies rather than the provision of highly active antiretroviral therapy (HAART) were the only feasible way to control the spread of HIV infection. Antiretroviral treatment is now cheaper thanks to initiatives from the pharmaceutical industry and generic manufacture and its wider availability ...
Rachael, Jones, Brian, Gazzard, Yasmin, Halima   +2 more
openaire   +2 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Handwashing Prevents Infection [PDF]

Drug Intelligence & Clinical Pharmacy, 1985
THE U.S. Department of Health and Human Services (HHS) is preparing to launch a nationwide infection control campaign. The campaign, called "Handwashing Prevents Infection...It really does!," uses the teddy bear character to present this important message in an appealing and persuasive manner.
openaire   +2 more sources