Results 21 to 30 of about 639,280 (301)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The impact of enhanced screening for carbapenemase-producing Enterobacterales in an acute care hospital in South Korea

Antimicrobial Resistance and Infection Control, 2023
Background Carbapenemase-producing Enterobacterales (CPE) poses a significant challenge to infection control in healthcare settings. Active screening is recommended to prevent intra-hospital CPE transmission.
Sun Hee Park, Yunmi Yi, Woosuck Suh, Seul Ki Ji, Eunhee Han, Soyoung Shin   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Plasma procalcitonin levels remain low at the onset of gram-positive bacteremia regardless of severity or the presence of shock: A retrospective analysis of patients with detailed clinical characteristics

Journal of Microbiology, Immunology and Infection, 2021
Objectives: Procalcitonin (PCT) is an early diagnosis marker of sepsis/bacteremia. However, some reports refer to its lower responsiveness to gram-positive bacteremia.
Yusuke Koizumi, Daisuke Sakanashi, Tomoko Ohno, Akiko Nakamura, Atsuko Yamada, Yuichi Shibata, Arufumi Shiota, Hideo Kato, Mao Hagihara, Nobuhiro Asai, Masaya Watarai, Kenta Murotani, Yuka Yamagishi, Hiroyuki Suematsu, Hiroshige Mikamo   +14 more
doaj   +1 more source

Impact of a Pay for Performance Strategy in the Improvement of Infection Prevention and Control Practices in Healthcare Facilities in the Context of the 2018 Ebola Virus Disease Outbreak in Nord Kivu: a quasi-experimental study [PDF]

, 2022
Landry Kabego, Mamadou Kourouma, Kevin Ousman, April Baller, Jean-Paul Milambo, John Kombe, Bienvenu Houndjo, Franck-Eric Boni, Castro Musafiri, Siya Mulembo, Stéphanie Kalumuna, Moise Tshongo, John Athanase, Nancy Moke, Clarisse Kumutima, Justin Nkita, Polydor Ngoma, Chedly Azzouz, Raphaël Okum, Michel Yao, Dick Chamla, Abdou Salam Guèye, Ibrahima Socé Fall   +22 more
openalex   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

High prevalence and clonal dissemination of OXA-72-producing Acinetobacter baumannii in a Chinese hospital: a cross sectional study

BMC Infectious Diseases, 2018
Background Carbapenem resistance in Acinetobacter baumannii in China was mainly mediated by OXA-23-like carbapenemases, while OXA-24/40-like carbapenemases were rarely identified. OXA-72 is one variant of OXA-24/40-like carbapenemases.
Yong Chen, Yuying Yang, Lin Liu, Guangbin Qiu, Xuelin Han, Shuguang Tian, Jingya Zhao, Fangyan Chen, Hajo Grundmann, Haifeng Li, Jinke Sun, Li Han   +11 more
doaj   +1 more source