Results 141 to 150 of about 5,975,057 (366)

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Impact of heterogeneity on infection probability: Insights from single-hit dose-response models [PDF]

open access: yesarXiv
The process of infection of a host is complex, influenced by factors such as microbial variation within and between hosts as well as differences in dose across hosts. This study uses dose-response and within-host microbial infection models to delve into the impact of these factors on infection probability. It is rigorously demonstrated that within-host
arxiv  

Finding an infection source under the SIS model [PDF]

open access: yesarXiv, 2013
We consider the problem of identifying an infection source based only on an observed set of infected nodes in a network, assuming that the infection process follows a Susceptible-Infected-Susceptible (SIS) model. We derive an estimator based on estimating the most likely infection source associated with the most likely infection path.
arxiv  

The initial configuration is irrelevant for the possibility of mutual unbounded growth in the two-type Richardson model [PDF]

open access: yesCombinatorics, Probability & Computing 15:3, 345-353 (2006), 2015
The two-type Richardson model describes the growth of two competing infections on $\mathbb{Z}^d$. At time 0 two disjoint finite sets $\xi_1,\xi_2\subset \mathbb{Z}^d$ are infected with type 1 and type 2 infection respectively. An uninfected site then becomes type 1 (2) infected at a rate proportional to the number of type 1 (2) infected nearest ...
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Nosocomial infections and infection control

open access: yesMedicine, 2017
Abstract Nosocomial infections are a leading cause of avoidable harm in hospital patients and a substantial, unnecessary drain on healthcare resources. They are frequently caused by bacteria that are resistant to multiple antibiotics, and the treatment of nosocomial infections contributes to the selection of resistant bacteria.
openaire   +2 more sources

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