Results 81 to 90 of about 2,055,886 (266)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Congenital Syphilis Prevention Challenges, Pacific Coast of Colombia, 2018–2022

Emerging Infectious Diseases
High incidences of congenital syphilis have been reported in areas along the Pacific coast of Colombia. In this retrospective study, conducted during 2018–2022 at a public hospital in Buenaventura, Colombia, we analyzed data from 3,378 pregnant women ...
Jose F. Fuertes-Bucheli, Diana P. Buenaventura-Alegría, Adriana M. Rivas-Mina, Robinson Pacheco-López   +3 more
doaj   +1 more source

Hospitalization rates for intussusception in children aged 0–59 months from 2009 to 2014 in Italy

Human Vaccines & Immunotherapeutics, 2017
The real cause of intussusception is not fully understood and a variety of conditions have been associated with it (Meckel diverticulum, polyps, duplication cysts, parasites, Henoch-Schönlein purpura, cystic fibrosis, hemolytic-uremic syndrome and ...
Vincenzo Restivo, Claudio Costantino, Fabio Tramuto, Francesco Vitale   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Analysis of Reported Cases of Giardia lamblia and Cryptosporidium spp. Infection in Children from Aragón (Northeast Spain) During the Period (2012–2021)

Microorganisms
Giardiasis and cryptosporidiosis, caused by Giardia lamblia and Cryptosporidium spp., are parasitic infections transmitted through faecal–oral routes or contaminated water.
Laura Lafarga-Molina, Encarnación Rubio, Cristina Seral, Antonio Rezusta, Pilar Egido Lizán, Carmen Malo Aznar, Josep-Oriol Casanovas-Marsal, María Teresa Fernández Rodrigo, Pilar Goñi   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A case of spontaneously arising strangely shaped scars

JAAD Case Reports, 2023
Ramesh M. Bhat, MBBS, MD, DNB, MNAMS, Jyothi Jayaraman, MBBS, DVL, DNB, Monisha Madhumita, MBBS   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Diagnostic Challenges in Pediatric Fever of Unknown Origin: Combined Role of Ferritin and Fever Duration

Children
Background: Fever of unknown origin (FUO) in children remains a diagnostic challenge due to heterogeneous etiologies. This study investigated the etiological distribution, long-term outcomes of undefined cases, and laboratory predictors that ...
Pınar Önal, Gözde Apaydın Sever, Beste Akdeniz Eren, Gülşen Kes, Esra Özek Yücel, Süheyla Ocak, Ayça Kıykım, Sezgin Şahin, Haluk Çokuğraş, Fatih Aygün, Özgür Kasapçopur, Fatma Deniz Aygün   +11 more
doaj   +1 more source