Results 61 to 70 of about 2,966,984 (355)

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

Angewandte Chemie, EarlyView.
AZD0156, an ATM kinase inhibitor in clinical development, shows promising multistage antiplasmodial activity by targeting Plasmodium falciparum phosphatidylinositol 4‐kinase (PfPI4Kβ). With an improved specificity profile relative to other PfPI4Kβ inhibitors and moderate efficacy in a P.
John G. Woodland, Dina Coertzen, Kathryn J. Wicht, Virginia Franco Hidalgo, Charisse Flerida A. Pasaje, Luiz C. Godoy, Tarrick Qahash, Mmakwena M. Mmonwa, Godwin A. Dziwornu, Lynn Wambua, Sarah Harries, Constance M. Korkor, Mathew Njoroge, Liezl Krugmann, Dale Taylor, Meta Leshabane, Henrico Langeveld, Tayla Rabie, Janette Reader, Mariëtte van der Watt, Nelius Venter, Erica Erlank, Ayesha S. Aswat, Lizette L. Koekemoer, Tomas Yeo, Jin H. Jeon, David A. Fidock, Francisco Javier Gamo, Sergio Wittlin, Jacquin C. Niles, Manuel Llinas, Lauren B. Coulson, Lyn‐Marié Birkholtz, Kelly Chibale   +33 more
wiley   +2 more sources

STUDY OF THE DISTRIBUTION OF PNEUMOCYSTOSIS IN BULGARIA BETWEEN SEPTEMBER 2017 AND APRIL 2019 BY USING REAL- TIME PCR

Problems of Infectious and Parasitic Diseases, 2019
Pneumocystis jirovecii is an opportunistic organism that inhabits predominantly the human pulmonary alveoli. The fully sequenced genome of P. jirovecii was first reported in 2012. According to some authors, P.
Aleksandra Ivanova, Nina Tsvetkova, Rumen Harizanov, Raina Borisova   +3 more
doaj   +1 more source

Major animal health problems of market oriented livestock development in Alamata woreda [PDF]

, 2010
An attempt was made to study major health problems of livestock in Alamata Woreda, northern Ethiopia, from December 2006 to April 2007. Questionnaire survey was carried out on 100 livestock owners to collect information on the livestock production system
Tekle, Y.
core  

A mean field analysis of the role of indirect transmission in emergent infection events [PDF]

Physica A 648:129933 (2024)
We developed a mathematical model to investigate the role of indirect transmission in the spread of infectious diseases, using the illustrative example of sarcoptic mange as a case study. This disease can be transmitted through direct contact between an infected host and a susceptible one, or indirectly when potential hosts encounter infectious mites ...
arxiv   +1 more source

Machine Learning for Infectious Disease Risk Prediction: A Survey [PDF]

arXiv, 2023
Infectious diseases, either emerging or long-lasting, place numerous people at risk and bring heavy public health burdens worldwide. In the process against infectious diseases, predicting the epidemic risk by modeling the disease transmission plays an essential role in assisting with preventing and controlling disease transmission in a more effective ...
arxiv  

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, EarlyView.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

INVESTIGATION OF MURINE RODENTS FOR THE PRESENCE OF LEPTOSPIRA DNA BY NESTED PCR

Problems of Infectious and Parasitic Diseases, 2019
Leptospirosis is a zooanthroponosis with natural foci. People become infected with leptospires either directly from host animals or by means of certain elements of the external environment.
Evgenia Taseva, Iva Christova, Elitsa Panayotova, Iva Trifonova   +3 more
doaj   +1 more source

A CASE OF VIBRIO VULNIFICUS INFECTION IN A DIABETES PATIENT WITH FATAL OUTCOME

Problems of Infectious and Parasitic Diseases, 2020
Aim. The aim of this report is to present the case of a 44-year-old male tourist from Belgium with type 1 diabetes who developed necrotizing fasciitis and sepsis caused by Vibrio vulnificus during his stay at the Bulgarian Black Sea Coast.
Maria Pavlova, K Tsankova, Rumiana Nenova, Iskra Tomova, V Velev, S Shishkov, Todor Kantardjiev   +6 more
doaj   +1 more source