Results 131 to 140 of about 1,221,083 (383)

CellPhenoX: An Explainable Machine Learning Method for Identifying Cell Phenotypes To Predict Clinical Outcomes from Single‐Cell Multi‐Omics

Advanced Science, EarlyView.
CellPhenoX is an explainable machine learning framework that identifies cell‐specific phenotypes and interaction effects from single‐cell omics data. By leveraging interpretable models, it enables robust discovery of cell‐level phenotypes that contribute to clinical outcomes.
Jade Young, Jun Inamo, Zachary Caterer, Revanth Krishna, Fan Zhang   +4 more
wiley   +1 more source

Exploring the molecular mechanisms and shared potential drugs between rheumatoid arthritis and arthrofibrosis based on large language model and synovial microenvironment analysis

Scientific Reports
Rheumatoid arthritis (RA) and arthrofibrosis (AF) are both chronic synovial hyperplasia diseases that result in joint stiffness and contractures. They shared similar symptoms and many common features in pathogenesis.
Zhaoquan Wei, Xi Chen, Youshi Sun, Yifei Zhang, Ruifang Dong, Xiaojing Wang, Shuangtao Chen   +6 more
doaj   +1 more source

Persistent haemagglutination for infectious mononucleosis in rheumatoid arthritis. [PDF]

, 1973
C A Horwitz, Herbert F. Polesky, T Stillman, Patrick C. J. Ward, Gertrude Henle, Werner Henle   +5 more
openalex   +1 more source

Resident Synovial Macrophages in Synovial Fluid: Implications for Immunoregulation in Infectious and Inflammatory Arthritis [PDF]

, 2023
Karen I. Cyndari, Breanna M. Scorza, Zeb R. Zacharias, Leela Strand, Kurayi Mahachi, Juan M. Oviedo, Lisa Gibbs, Danielle Pessôa-Pereira, Graham Ausdal, Dylan Hendricks, Rika Yahashiri, Jacob M. Elkins, Trevor R. Gulbrandsen, Andrew R. Peterson, Michael Willey, Keke C. Fairfax, Christine A. Petersen   +16 more
openalex   +1 more source

Personalized Medication for Chronic Diseases Using Multimodal Data‐Driven Chain‐of‐Decisions

Advanced Science, EarlyView.
A MDD‐CoD is proposed for personalized chronic disease medication. The framework simulates clinical chain‐of‐decisions through three linked deep learning tasks, validated on multi‐center datasets (3 hospitals, 4 diseases), demonstrating enhanced generalization and interpretability in cross‐disease applications.
Xiaoli Chu, Yiheng Ye, Siqiao Tang, Miaoru Han, Guowei Wang, Shuai Lin, Bingzhen Sun, Qingchun Huang, Yan Zhang, Xiaodong Chu, Kun Bao   +10 more
wiley   +1 more source

Pseudoseptic Reaction to an Intra-Articular Polydeoxyribonucleotide Injection into the Ankle: A Case Report

International Journal of Pain
Pseudoseptic arthritis is a rare complication mimicking septic arthritis following intra-articular injections. While hyaluronic acid (HA) has been the primary agent linked to such reactions, we report a case of pseudoseptic arthritis after ...
Seungcheol Yu, Hangaram Kim, Youngwoong Choi, Jeongsoo Kim   +3 more
doaj   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers. [PDF]

, 2020
The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during ...
Barcellos, Lisa F, Blasczyk, Rainer, Busch, Michael P, Criswell, Lindsey A, Cruz, Giovanna I, Ho, Kimberly A, Ladas, Nektarios, Niederhuber, John E, Noble, Janelle A, Patsopoulos, Nikolaos A, Quach, Diana, Quach, Hong, Shao, Xiaorong, Solomon, Benjamin D, Sterba, Kirsten, Triulzi, Darrell J, Wong, Wendy SW   +16 more
core  

BLOC1S1 Attenuates B. Melitensis 16M LPS‐Triggered Autophagy by Spatial Confinement of TDP‐43

Advanced Science, EarlyView.
This study explores how B. melitensis 16M LPS and BLOC1S1 regulate autophagy in goat spermatogonial stem cells. The 16M LPS is activating AMPK‐dependent autophagy, increasing LC3B‐II/I ratios and lysosomal genes, while Escherichia coli LPS shows no effect.
Shicheng Wan, Miao Han, Mengfei Zhang, Wenbo Chen, Fangde Xie, Xuan Luo, Wenping Wu, Congliang Wang, Donghui Yang, Bin Han, Haijing Zhu, Haisheng Yu, Na Li, Jinlian Hua   +13 more
wiley   +1 more source

Diagnostic challenges in pediatric arthritis: A case of systemic juvenile idiopathic arthritis misdiagnosed as septic arthritis in a 3-year-old boy

SAGE Open Medical Case Reports
Arthritis in children has several causes, including infectious, inflammatory, and infiltration of malignant cells, and it is important to differentiate them as soon as possible.
Sogol Alesaeidi, Mohsen Jari
doaj   +1 more source