Results 161 to 170 of about 7,009,349 (302)

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Development and Clinical Evaluation of an LC-MS/MS Method for the Determination of Isoniazid in Cerebrospinal Fluid from Tuberculous Meningitis

Infection and Drug Resistance
Mingming Xin,1,* Jiabin Liang,2,* Minggui Lin,1 Xiaohui Wang,1 Wenjing Hou,1 Leping Zhong,1 Xuzhu Ma,1 Xiwei Ji2 1Department of Infectious Diseases, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine ...
Xin M, Liang J, Lin M, Wang X, Hou W, Zhong L, Ma X, Ji X   +7 more
doaj  

APEC and Infectious Disease : Meeting the Challenge [PDF]

This paper considers how the Asia Pacific Economic Cooperation (APEC) process, given its institutional characteristics, can contribute to the efforts undertaken by the World Health Organisation (WHO) against infectious disease (ID).
Joel Gilbourd
core  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Health inequalities in infectious disease modelling. [PDF]

Commun Health
Eggo RM, Robert A, Khunti K, Clapham HE.
europepmc   +1 more source

Lyme disease : a public information guide [PDF]

Lyme disease was first recognized in the United States in 1975 after an unusual outbreak of arthritis near Lyme, Connecticut. Since then, reports of Lyme disease have increased dramatically, and the disease has become an important public health problem ...

core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Barry Bloom and the convergence of immunology, infectious disease, and public health. [PDF]

Proc Natl Acad Sci U S A
Fortune SM, Jacobs WR, Casadevall A.
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

A New landscape for combatting infectious disease [PDF]

Advances in science and technology aimed at identifying the complete genetic makeup of microorganisms are ushering in a new era for controlling infectious threats. By using genetic sequencing to examine infectious pathogens, these technologies are on the
Centers for Disease Control and Prevention (U.S.)
core