Results 191 to 200 of about 154,289 (311)

Assessment of High-Volume Antibiotic and Opioid Prescribing by Medicare Part D Prescribers-United States, 2021. [PDF]

Public Health Rep
Vazquez Deida AA, Kim C, Gouin KA, Zhang K, Mikosz CA, Neuhauser MM, Kabbani S.   +6 more
europepmc   +1 more source

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

Advanced Science, EarlyView.
The axon initial segment (AIS), crucial for action potential initiation, serves as a prime locus for controlling network activity. Chandelier Cells (ChCs), evolved in the mammals, intricately target AISs, acting as gatekeepers for neuronal firing. Diminishing ChC input makes animals more prone to developing seizures, whereas fortifying this connection ...
Yang Li, Jifeng Tian, Jiafan Wei, Qianyun Wang, Jiaxu Ge, Jianguang Ni, Jiangteng Lu, Yilin Tai   +7 more
wiley   +1 more source

<i>Mycoplasma pneumoniae</i> re-emergence in 2023 causes disease in adults in Europe. [PDF]

ERJ Open Res
Streng BMM, Bont LJ, Meyer Sauteur PM, Bonten MJM, van Rossum AMC, Prat Aymerich C.   +5 more
europepmc   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

Analysis of factors influencing high infectivity in patients with tuberculosis using clinical and imaging methods. [PDF]

BMC Infect Dis
Han J, Ding W, Yang W, Xing Z, Li X, Li Y, Xie Y, Wan Z.   +7 more
europepmc   +1 more source

Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH‐Mutant Glioma

Advanced Science, EarlyView.
IDH‐mutant gliomas exhibit sensitivity to PARP inhibitors (PARPi) owing to oncometabolite 2‐HG‐induced DNA repair defects. PARPi treatment induces resistance by upregulating Prickle4, which promotes VEGF‐driven angiogenesis. Combining PARPi veliparib with anti‐angiogenic lenvatinib blocks this pathway, causing tumor regression and prolonged survival in
Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T. Huse, Bo Chen, Timothy A. Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang   +16 more
wiley   +1 more source

Preventing Antimicrobial Resistance Together: Reflections on AMR Week 2023

Journal of Epidemiology and Global Health
Jaffar A. Al-Tawfiq, Shahul H. Ebrahim, Ziad A. Memish   +2 more
doaj   +1 more source

Guiding Antibiotic Therapy with Machine Learning: Real-World Applications of a CDSS in Bacteremia Management. [PDF]

Life (Basel)
Gómez de la Torre JC, Frenkel A, Chavez-Lencinas C, Rendon A, Higuchi Y, Vela-Ruiz JM, Calpey J, Beaton R, Elijah I, Shachar I, Kim E, Valencia Osorio S, Lee JJ, Grogan G, Siegel J, Allman S, Hueda-Zavaleta M.   +16 more
europepmc   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Prevalence of cognitive morbidity including delirium in 51,202 emergency hospital admissions across 29 medical and surgical specialties in ORCHARD-EPR: a cross-sectional study. [PDF]

EClinicalMedicine
Boucher EL, Smith SC, Singh S, Shepperd S, Pendlebury ST.   +4 more
europepmc   +1 more source