Results 201 to 210 of about 152,680 (306)

Lack of adherence to evidence-based treatment guidelines for nontuberculous mycobacterial lung disease.

Annals of the American Thoracic Society, 2014
J. Adjemian, D. R. Prevots, J. Gallagher, K. Heap, Renu Gupta, David E. Griffith   +5 more
semanticscholar   +1 more source

MERS-CoV remains a persistent threat amid global events

Journal of Infection and Public Health
Jaffar A. Al-Tawfiq, Sameera Al Johani, Ziad A. Memish   +2 more
doaj   +1 more source

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Impact of COVID-19 on the awareness and interest in infectious disease specialization among Japanese medical students. [PDF]

PLoS One
Kamada N, Hagiya H, Kutsuna S.
europepmc   +1 more source

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

Improving osteoporosis prevention and care for patients with HIV: insights from HIV care providers in China. [PDF]

BMC Health Serv Res
Tseng LY, Pan W, Zhao Y, Curry LA, Hsieh E, Li T.   +5 more
europepmc   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

The Role of Electronic Medical Record Automation in Latent Tuberculosis Screening and Treatment in a Large Health System. [PDF]

Open Forum Infect Dis
Li H, Polesky A, Cervenka A, Sahni H.
europepmc   +1 more source

Missed opportunities to prescribe HIV pre-exposure prophylaxis by primary care providers in Saint Louis, Missouri [PDF]

, 2018
Chan, Philip A, Harrison, Laura C, Mayer, Kenneth H, Mena, Leandro A, Nunn, Amy, Patel, Rupa R, Powderly, William G   +6 more
core   +2 more sources

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

Advanced Science, EarlyView.
The axon initial segment (AIS), crucial for action potential initiation, serves as a prime locus for controlling network activity. Chandelier Cells (ChCs), evolved in the mammals, intricately target AISs, acting as gatekeepers for neuronal firing. Diminishing ChC input makes animals more prone to developing seizures, whereas fortifying this connection ...
Yang Li, Jifeng Tian, Jiafan Wei, Qianyun Wang, Jiaxu Ge, Jianguang Ni, Jiangteng Lu, Yilin Tai   +7 more
wiley   +1 more source