Results 41 to 50 of about 5,368,093 (295)

Disease outbreak in wildlife changes online sales of management items

One Health
Infectious diseases of wildlife cause human health hazards and economic losses. However, it is unclear how outbreaks affect human behaviour in relation to countermeasures against human–wildlife conflict.
Tomohiko Endo, Shinya Uryu, Keita Fukasawa, Jiefeng Kang, Takahiro Kubo   +4 more
doaj   +1 more source

The impact of organisational characteristics of staff and facility on infectious disease outbreaks in care homes: a systematic review

BMC Health Services Research, 2022
Background Infectious disease outbreaks are common in care homes, often with substantial impact on the rates of infection and mortality of the residents, who primarily are older people vulnerable to infections.
Liljas AEM, L. P. Morath, B. Burström, P. Schön, J. Agerholm   +4 more
doaj   +1 more source

A Data-Validated Host-Parasite Model for Infectious Disease Outbreaks

Frontiers in Ecology and Evolution, 2019
The use of model experimental systems and mathematical models is important to further understanding of infectious disease dynamics and strategize disease mitigation.
Christina P. Tadiri, Jude D. Kong, Gregor F. Fussmann, Marilyn E. Scott, Hao Wang   +4 more
doaj   +1 more source

Extreme weather events and infectious disease outbreaks [PDF]

Virulence, 2015
Human-driven climatic changes will fundamentally influence patterns of human health, including infectious disease clusters and epidemics following extreme weather events. Extreme weather events are projected to increase further with the advance of human-driven climate change.
openaire   +3 more sources

Global rise in human infectious disease outbreaks [PDF]

Journal of The Royal Society Interface, 2014
To characterize the change in frequency of infectious disease outbreaks over time worldwide, we encoded and analysed a novel 33-year dataset (1980–2013) of 12 102 outbreaks of 215 human infectious diseases, comprising more than 44 million cases occuring in 219 nations.
Katherine F, Smith, Michael, Goldberg, Samantha, Rosenthal, Lynn, Carlson, Jane, Chen, Cici, Chen, Sohini, Ramachandran   +6 more
openaire   +3 more sources

Life histories offer a clue to the future role of infectious disease in coral reefs [PDF]

, 2012
Increased frequency and severity of stressors associated with climate change are drastically altering ecosystems. Caribbean coral reefs differ markedly from just 30 years ago, with much restructuring attributable to infectious disease outbreaks.
Mumby, P. J., Mumby, Peter, YAKOB, L, Yakob, L., MUMBY, PJ, Yakob, Laith   +5 more
core   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Climate variability and outbreaks of infectious diseases in Europe [PDF]

Scientific Reports, 2013
Several studies provide evidence of a link between vector-borne disease outbreaks and El Niño driven climate anomalies. Less investigated are the effects of the North Atlantic Oscillation (NAO). Here, we test its impact on outbreak occurrences of 13 infectious diseases over Europe during the last fifty years, controlling for potential bias due to ...
Morand, Serge, Owers, Katharine, Waret-Szkuta, Agnès, McIntyre, K. Marie, Baylis, Matthew   +4 more
openaire   +4 more sources

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source