Results 31 to 40 of about 5,837,960 (266)

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

The epidemiology of carbapenem resistance in Acinetobacter baumannii complex in Germany (2014–2018): an analysis of data from the national Antimicrobial Resistance Surveillance system

Antimicrobial Resistance and Infection Control, 2021
Background Carbapenem-resistant Acinetobacter baumannii complex (CRABC) has globally emerged as a serious public health challenge. This study aimed to describe epidemiological trends and risk factors of carbapenem resistance in A.
Dunja Said, Niklas Willrich, Olaniyi Ayobami, Ines Noll, Tim Eckmanns, Robby Markwart   +5 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Methods for determining disease burden and calibrating national surveillance data in the United Kingdom: the second study of infectious intestinal disease in the community (IID2 study) [PDF]

, 2010
Background: Infectious intestinal disease (IID), usually presenting as diarrhoea and vomiting, is frequently preventable. Though often mild and self-limiting, its commonness makes IID an important public health problem.
Gray James J, Cowden, JM, Evans, Meirion R, Rodrigues, L.C, Neal, Keith R, Tompkins, David S, O'Brien Sarah J, Gray, JJ, Rodrigues, LC, Neal Keith R, Smith, GE, Hunter, P.R, Hunter, Paul R., Goutam K Adak, Sarah J O'Brien, Hunter, Paul R, Tompkins David S, Tompkins, D.S, Clarence C Tam, Evans, MR, Rait Greta, Gillian E Smith, Rait, G, O'Brien, Sarah J., Bolton, Frederick J, Adak, GK, Adak Goutam K, Hunter, PR, Smith Gillian E, Bolton, Frederick J., Adak, Goutam K., McLauchlin Jim, Letley, L.H, Smith, Gillian E., McLauchlin, J, McLauchlin, Jim, Letley Louise H, Evans Meirion R, Smyth, Brian, Hunter Paul R, Laura C Rodrigues, Jim McLauchlin, Louise H Letley, Letley, LH, Letley, Louise H, Rodrigues, Laura C, Smyth Brian, Rait, Greta, Adak, G.K, Gray, James J, Tam, Clarence C., Cowden, J.M, Neal, K.R, Adak, Goutam K, O'Brien, Sarah J, Keith R Neal, Cowden, John M., Cowden John M, Bolton Frederick J, Paul R Hunter, David S Tompkins, John M Cowden, Evans, Meirion R., Gray, James J., Neal, KR, Greta Rait, Brian Smyth, O'Brien, S.J, Tam Clarence C, Bolton, F.J, Neal, Keith R., Meirion R Evans, Evans, M.R, Tam, Clarence C, O'Brien, SJ, Rodrigues Laura C, Smyth, B, Frederick J Bolton, Smith, Gillian E, Tompkins, David S., Tam, CC, Smith, G.E, Bolton, FJ, James J Gray, Tompkins, DS, Rodrigues, Laura C., Cowden, John M, Gray, J.J, Letley, Louise H., Tam, C.C   +89 more
core   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Mortality and causes of death in people diagnosed with HIV in the era of highly active antiretroviral therapy compared with the general population: an analysis of a national observational cohort

The Lancet Public Health, 2017
Background: Deaths in HIV-positive people have decreased since the introduction of highly active antiretroviral therapy (HAART) in 1996. Fewer AIDS-related deaths and an ageing cohort have resulted in an increase in the proportion of HIV patients dying ...
Sara Croxford, MSc, Aileen Kitching, MFPH, Sarika Desai, MSc, Meaghan Kall, MSc, Michael Edelstein, MFPH, Andrew Skingsley, MRCP, Fiona Burns, FRCP, Andrew Copas, PhD, Alison E Brown, PhD, Ann K Sullivan, FRCP, Valerie Delpech, FPHM   +10 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

The epidemiology of carbapenem-non-susceptible Acinetobacter species in Europe: analysis of EARS-Net data from 2013 to 2017

Antimicrobial Resistance and Infection Control, 2020
Background Due to limited therapeutic options and their association with high mortality and morbidity, carbapenem-non-susceptible Acinetobacter spp. (CNA) are of significant public health importance.
Olaniyi Ayobami, Niklas Willrich, Beneditta Suwono, Tim Eckmanns, Robby Markwart   +4 more
doaj   +1 more source

Assessment of hybrid population immunity to SARS-CoV-2 following breakthrough infections of distinct SARS-CoV-2 variants by the detection of antibodies to nucleoprotein

Scientific Reports, 2023
Immunity induced by vaccination and infection, referred to as hybrid immunity, provides better protection against SARS-CoV-2 infections compared to immunity induced by vaccinations alone.
Gerco den Hartog, Stijn P. Andeweg, Christina E. Hoeve, Gaby Smits, Bettie Voordouw, Dirk Eggink, Mirjam J. Knol, Robert S. van Binnendijk   +7 more
doaj   +1 more source

Infectious intestinal disease : do we know it all? [PDF]

, 2006
Infectious intestinal disease (IID), with associated high morbidity and considerable mortality worldwide, causes a wide spectrum of illness. This ranges from mild discomfort to illness with severe complications.
Gauci, Charmaine, Mamo, Julian, Gilles, Herbert M., O’Brien, Sarah J.   +3 more
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