Results 51 to 60 of about 5,837,960 (266)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Longitudinal study of infectious intestinal disease in the UK (IID2 study): incidence in the community and presenting to general practice [PDF]

, 2011
Objectives To estimate, overall and by organism, the incidence of infectious intestinal disease (IID) in the community, presenting to general practice (GP) and reported to national surveillance.
Evans, Meirion R, Rait, Greta, Evans, Meirion Rhys, Tompkins, David S, Gray, Jim J., Rodrigues, LC, Gray, JJ, Tam, Clarence C., IID2 Study Executive Committee, Hunter, Paul R., O'Brien, Sarah J, Jim J Gray, Sarah J O'Brien, Hunter, Paul R, Clarence C Tam, Evans, MR, O'Brien, Sarah J., Rait, G, Paul R Hunter, David S Tompkins, Evans, Meirion R., Laura Viviani, Dodds, Julie P, Hunter, PR, Greta Rait, Julie P Dodds, Meirion R Evans, Tam, Clarence C, O'Brien, SJ, Gray, Jim J, Dodds, JP, Tompkins, David S., Tam, CC, Laura C Rodrigues, Viviani, Laura, Louise H Letley, Tompkins, DS, Letley, Louise H, Letley, LH, Viviani, L, Rodrigues, Laura C., Rodrigues, Laura C, Dodds, Julie P., Letley, Louise H.   +43 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Surveillance-response systems : the key to elimination of tropical diseases [PDF]

, 2014
Tropical diseases remain a major cause of morbidity and mortality in developing countries. Although combined health efforts brought about significant improvements over the past 20 years, communities in resource-constrained settings lack the means of ...
Zhou, Xiao-Nong, Robert Bergquist, Jun-Hu Chen, Utzinger, Jürg, Wei Hu, Ai, Lin, Bergquist, Robert, Tambo, Ernest, Xia Zhou, Marcel Tanner, Chen, Jun-Hu, Guo, Jia-Gang, Zhou, Xia, Ernest Tambo, Hu, Wei, Xiao-Nong Zhou, Jürg Utzinger, Lin Ai, Jia-Gang Guo, Tanner, Marcel, Hughes, Wei   +20 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Strengthening governance and leadership of the national laboratory system in Liberia: achievements and challenges

Frontiers in Public Health
BackgroundLiberia’s health system, severely impacted by prolonged conflict and the 2014–2015 Ebola outbreak, suffered from critical gaps in laboratory governance, workforce capacity, and diagnostic infrastructure.
Torbandu H. Kohar, Ellen Munemo, Jonathan Kpaka, Nisha Marles, Ochiawunma Akwiwu-Ibe, Anicet G. Dahourou, Frantz Jean Louis   +6 more
doaj   +1 more source

Recent household transmission of tuberculosis in England, 2010–2012: retrospective national cohort study combining epidemiological and molecular strain typing data

BMC Medicine, 2017
Background We estimate the proportion of tuberculosis (TB) in England due to recent household transmission, identify factors associated with being a household transmitter, and investigate the impact that identification of a case has on time to treatment ...
Maeve K. Lalor, Laura F. Anderson, Esther L. Hamblion, Andy Burkitt, Jennifer A. Davidson, Helen Maguire, Ibrahim Abubakar, H. Lucy Thomas   +7 more
doaj   +1 more source

Weekly Influenza Surveillance Report Week 20 2002 [PDF]

, 2002
This is the final influenza surveillance report for this season. Influenza surveillance reports will resume in October 2002 for the 2002/2003 influenza season.
National Disease Surveillance Centre (NDSC), National Virus Reference Laboratory (NVRL), Irish College of General Practitioners (ICGP)   +2 more
core  

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Prospective surveillance of invasive group a streptococcal disease, Fiji, 2005-2007. [PDF]

, 2009
We undertook a prospective active surveillance study of invasive group A streptococcal (GAS) disease in Fiji over a 23-month period, 2005-2007. We identified 64 cases of invasive GAS disease, which represents an average annualized all-ages incidence of 9.
Adam Jenney, E. Kim Mullholland, Batzloff, M, Steer, AC, Jonathan R. Carapetis, Kado, Joseph, Carapetis, JR, Good, Michael F, Carapetis, Jonathan R., Waqatakirewa, L, Jenney, A, Mullholland, E Kim, Jenney, Adam, Kado, J, Steer, Andrew C., Carapetis, Jonathan R, Andrew C. Steer, Good, Michael F., Lepani Waqatakirewa, Good, MF, Waqatakirewa, Lepani, Steer, Andrew C, Joseph Kado, Michael Batzloff, Michael F. Good, Mullholland, EK, Batzloff, Michael, Kim Mullholland, E.   +27 more
core   +1 more source