Results 171 to 180 of about 159,179 (308)

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Rift Valley fever virus-infected mosquito ova and associated pathology: possible implications for endemic maintenance

Research and Reports in Tropical Medicine, 2011
William S Romoser1, Marco Neira Oviedo1, Kriangkrai Lerdthusnee2, Lisa A Patrican3, Michael J Turell4, David J Dohm4, Kenneth J Linthicum5, Charles L Bailey61Department of Biomedical Sciences, College of Osteopathic Medicine, Tropical Disease Institute ...
Romoser WS, Oviedo MN, Lerdthusnee K, Patrican LA, Turell MJ, Dohm DJ, Linthicum KJ, Bailey CL   +7 more
doaj  

Long‐term trends in parasite diversity and infection levels: approaches and patterns

Biological Reviews, EarlyView.
ABSTRACT Parasites exist in every ecosystem, affecting nearly all organisms and playing a complex role in human societies. On the one hand, they contribute substantially to biodiversity and support ecosystem stability by performing essential ecological functions.
Cyril Hammoud, Juan Antonio Balbuena, Isabel Blasco‐Costa, Katie O'Dwyer, Rachel A. Paterson, Tomáš Scholz, Christian Selbach, Bernd Sures, David W. Thieltges   +8 more
wiley   +1 more source

The spread of non‐native species

Biological Reviews, EarlyView.
ABSTRACT The global redistribution of species through human agency is one of the defining ecological signatures of the Anthropocene, with biological invasions reshaping biodiversity patterns, ecosystem processes and services, and species interactions globally.
Phillip J. Haubrock, Ali Serhan Tarkan, Irene Martín‐Forés, Stelios Katsanevakis, Ronaldo Sousa, Ismael Soto, Andy J. Green, Antonín Kouba, Teun Everts, Victoria Dominguez Almela, Nadège Belouard, Cang Hui, Jamie Bojko, Victor Deklerck, Margaux Boeraeve, Franz Essl, J. Robert Britton   +16 more
wiley   +1 more source

Congenital babesiosis in China: first molecularly confirmed case of vertical transmission of <i>Babesia microti</i>. [PDF]

Emerg Microbes Infect
Liu J, Li D, Wang S, Gao S, Xu B, Zhao J, Liu Q, Chen M, Zhou X, Cai Y, He L.   +10 more
europepmc   +1 more source

Characteristics of and factors associated with infectious disease hospital admissions in children by HIV-exposure status in an era of high coverage of prevention of vertical HIV transmission in the Western Cape Province of South Africa

In South Africa, an estimated 22% of children under age 15 years are exposed to HIV and uninfected (HEU). Since the implementation of lifelong antiretroviral therapy (ART) for all pregnant women living with HIV in 2013 (Option B+) and all individuals living with HIV in 2016 (Universal ART), the proportion of children conceived while their mothers are ...
openaire   +1 more source

Faecal Microbiota Transplantation in Anorexia Nervosa: A Systematic Review of Methodologies, Outcomes, and Challenges With Recommendations for Future Studies

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder displaying an altered gut microbiome. Faecal microbiome transplantation (FMT) has emerged as a powerful research tool and potential treatment option in AN due to the microbiome‐gut‐brain axis. Current studies are limited and reveal variable FMT protocols.
Anna C. Thelen, Nele M. Korten, Larissa Blischke, Clara Voelz, Cordian Beyer, Jochen Seitz, Stefanie Trinh   +6 more
wiley   +1 more source

Viral haemorrhagic septicaemia virus, infectious haematopoietic necrosis virus and HPR-deleted infectious salmon anaemia virus - Risk of introduction in free areas through fertilised eggs and gametes. [PDF]

EFSA J
EFSA Panel on Animal Health and Welfare (AHAW), Nielsen SS, Alvarez J, Boklund A, Dippel S, Figuerola J, Herskin MS, Michel V, Miranda Chueca MA, Nannoni E, Nonno R, Riber AB, Ståhl K, Stegeman JA, Thulke HH, Tuyttens F, Winckler C, Christiansen DH, Olesen NJ, Rimstad E, Toffan A, Vendramin N, Papaleo S, Preite L, Baldinelli F, Dórea F.   +25 more
europepmc   +1 more source

Calcitonin gene‐related peptide concentration in cerebrospinal fluid and serum in horses affected by trigeminal‐mediated headshaking

Equine Veterinary Journal, EarlyView.
Abstract Background Trigeminal‐mediated headshaking (TMHS) in horses shares clinical features with human trigeminal neuralgia (HTN). Increased levels of the neuropeptide calcitonin gene‐related peptide (CGRP) have been found in the blood and cerebrospinal fluid (CSF) of HTN patients. Inhibition of CGRP in humans has shown promise for pain relief.
Lisa Annabel Weber, Hilke Oltmanns, Ludovica Chiavaccini, Kirstie J. Pickles, Veronica Roberts, Tanja Kloock, Tobias Niebuhr, Karsten Feige   +7 more
wiley   +1 more source