Results 91 to 100 of about 3,979,167 (303)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The Prevention of Early-Onset Group B Streptococcal Infections in the Newborn
Canadian Journal of Infectious Diseases, 1994 Infectious Diseases and Immunization Committee
doaj +1 more source
Nihon Naika Gakkai Zasshi, 1999 1999年4月1日から施行された感染症の予防及び感染症の患者に対する医療に関する法律においては,これまでは全く異なった1類感染症, 2類感染症, 3類感染症, 4類感染症,指定感染症及び新感染症からなる感染症類型が設けられている.指定感染症は,旧法である伝染病予防法においても規定されていた事項であるが,感染症新法では,適応に当たっての手続保障の厳格化等を講じている.本稿では,指定感染症と新感染症の相違点を中心に感染症類型を概説する.
openaire +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Canadian Journal of Infectious Diseases, 1995 Infectious Diseases and Immunization Committee
doaj +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Interdisciplinary Perspectives on Infectious Diseases, 2016 Interdisciplinary Perspectives on Infectious Diseases
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source