Results 51 to 60 of about 30,028 (256)

HLA-B27 Positivity: associated health implications [PDF]

, 2011
HLA-B27 positivity makes the onset of autoimmune diseases such as uveitis, ankylosing spondylitis and Crohn's disease more likely to occur. Ankylosing spondylitis and Crohn's disease are two types of HLA-B27 positive diseases that demonstrate a direct ...
Cox, C. L., Evans, P., Gibbons, H., Titmus, K., Withers, T.   +4 more
core   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Analysis of the human diseasome reveals phenotype modules across common, genetic, and infectious diseases [PDF]

, 2014
Phenotypes are the observable characteristics of an organism arising from its response to the environment. Phenotypes associated with engineered and natural genetic variation are widely recorded using phenotype ontologies in model organisms, as are signs
Gkoutos, Georgios V, Hoehndorf, Robert, Schofield, Paul N   +2 more
core   +2 more sources

Increased Anti‐Psoriatic Effect of Anti‐Inflammatory Dendrimers Using Fluid Catanionic Vesicle‐Based Topical Formulations

Advanced Healthcare Materials, EarlyView.
Next‐Generation Psoriasis Therapy – With advanced dendrimer‐based formulations, this study paves the way for highly effective, skin‐permeable treatments. Encapsulated in fluid catanionic vesicles, IMD‐006 and its analogues show promising anti‐psoriatic effects offering a targeted, non‐invasive approach to managing chronic skin inflammation.
Ranime Jebbawi, Abdelouahd Oukhrib, Emily Clement, Hélène Labie, Stéphanie Cassel, Séverine Fruchon, Anne‐Marie Caminade, Michel Simon, Rémy Poupot, Cédric‐Olivier Turrin, Muriel Blanzat   +10 more
wiley   +1 more source

Demography in Swiss paediatric uveitis: a retrospective cohort study

Journal of Ophthalmic Inflammation and Infection
Introduction Paediatric uveitis is a rare disease. It can affect any segment and have various etiologies, including infectious, autoimmune, and masquerade diseases.
Jeanne Martine Gunzinger, Alice Kitay, Fabio Meier, Christian Böni, Seraina Palmer Sarott, Brigitte Simonsz-Tóth, Christina Gerth-Kahlert   +6 more
doaj   +1 more source

PCR em tempo real em uveites infecciosas como um diagnóstico alternativo [PDF]

, 2011
PURPOSE: Uveitis is a major visual impairment disease affecting parts or the entire uveal tract and occasionally the sclera, the cornea or the optic nerve.
Belfort, Rubens Junior, Commodaro, Alessandra Gonçalves, Garcia, Claudio, Lottenberg, Cláudio Luiz, Muccioli, Cristina, Pinho, João Renato Rebello, Ribeiro, Ana Lúcia Pereira, Rizzo, Luiz Vicente, Santos, Fabio Felipe dos, Sitnik, Roberta, Souza, Andrea Vieira de   +10 more
core   +2 more sources

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Oral Celastrol Nanomedicine Targeting Intestinal Antigen‐Presenting Cells to Effectively Mitigate Autoimmune Uveitis via Gut‐Retina Axis

Advanced Science, EarlyView.
Oral nanoCEL exhibits effective intestinal targeting of antigen‐presenting cells and restores the Th17/Treg balance in lymph nodes and spleen, ultimately protecting the blood‐retinal barrier by inhibiting peripheral immune cell infiltration and suppressing retinal glial cell activation.
Jinrun Chen, Yuqin Wu, Bofei Xu, Jiabei Hou, Yijing Li, Yuhan Hu, Yutuo Zhu, Wenqiao Zhang, Shuqi Feng, Huanting Jin, Yuchen Cheng, Yuanyuan Jin, Jianhong Zhou, Xingyi Li   +13 more
wiley   +1 more source

Quantitative levels of interferon gamma as a biomarker in the aqueous and serum samples of infectious and noninfectious uveitis patients

Journal of Ophthalmic Inflammation and Infection
Background To study the utility of interferon gamma (IFN-γ) as a differentiating biomarker by assessing the aqueous humour and serum of patients with infectious and noninfectious uveitis.
Sahar Saad Eldeen Mohamed Shaban, Hend Mohammed Safwat, Abeer Mohammed Abdelmohymen, Donia Ahmed Hassan, Mona Nabeh Mansour, Hanan Said Mohammed, Nora Seliem, Shahinaz El Attar, Doaa Refaat Amin, Seham Kamal Ahmed Khirala, Aya Ahmed Ghamry, Mona Gamal El Din Al Anany, Shaymaa Fathy Mohammed   +12 more
doaj   +1 more source

Low-volume multiplex solid-phase PCR without DNA extraction for etiological diagnosis of infectious uveitis

Indian Journal of Ophthalmology
Purpose: To evaluate the usefulness of a low-volume multiplex direct polymerase chain reaction (PCR) in identifying pathogens in intraocular fluid in infectious uveitis. Design: Prospective interventional non-comparative study.
Eduardo Ferracioli-Oda, Tatiana Tanaka, Michele Soares Gomes Gouvea, João Renato Rebello Pinho, Verônica Coelho, Paulo José Martins Bispo, Carlos Eduardo Hirata, Joyce Hisae Yamamoto   +7 more
doaj   +1 more source