Results 71 to 80 of about 2,047,991 (338)
Robust inference for geographic regression discontinuity designs: assessing the impact of police precincts [PDF]
, 2021 Emmett B. Kendall +2 more
openalex +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
TICTAC: target illumination clinical trial analytics with cheminformatics
Frontiers in BioinformaticsIntroductionIdentifying disease–target associations is a pivotal step in drug discovery, offering insights that guide the development and optimization of therapeutic interventions.
Jeremiah I. Abok +2 more
doaj +1 more source
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1953 Summary The subject matter of mathematical statistics may be divided into two parts, the theory of probability and the theory of inference. The first is concerned with deductions from the population to the sample; the second with inferences from the sample to the population, and may further be subdivided into the design and analysis of ...
openaire +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Probabilistic Alternatives to Bayesianism: The Case of Explanationism
Frontiers in Psychology, 2015 There has been a probabilistic turn in contemporary cognitive science. Far and away, most of the work in this vein is Bayesian, at least in name. Coinciding with this development, philosophers have increasingly promoted Bayesianism as the best normative ...
Igor eDouven, Jonah N. Schupbach
doaj +1 more source
Task-Specific Data Augmentation and Inference Processing for VIPriors Instance Segmentation Challenge [PDF]
, 2022 Bo Yan +3 more
openalex +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Inference Analysis in Netizen Opinions on the Issue of Owners of Skincare Money Laundry
Prasasti: Journal of LinguisticsThe research entitled Inference Analysis in Netizen Opinions on the Tik Tok Shop Closing Issue aims to describe Yohan Agustin's YouTube channel and several Tik Tok content creators regarding the issue of Money Laundry Owner Skincare.
Clementina Vincencia Kandam +1 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source