Results 81 to 90 of about 451,855 (262)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Rethinking I/O Caching for Large Language Model Inference on Resource-Constrained Mobile Platforms
MathematicsLarge language models (LLMs) have traditionally relegated inference to remote servers, leaving mobile devices as thin clients. Recently, advances in mobile GPUs and NPUs have made on-device inference increasingly feasible, particularly for privacy ...
Heejin Kim, Jeongha Lee, Hyokyung Bahn
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Chaos Theory and ApplicationsThe aim of this study is to forecast the amount of tax complaints filed with the Turkish Ombudsman in the future and whether or not policymakers require a specific tax Ombudsman.
Mehmet Niyazi Çankaya, Murat Aydın
doaj +1 more source
Frontiers in Psychology, 2013 Recent research has shown that the perception of causality affects the judgment of elapsed time: An interval between an action and a subsequent event seems to be shorter when people believe that action has caused the event. This article reviews past work
David eFaro, Ann L. McGill, Reid eHastie
doaj +1 more source
Information and Inference [PDF]
Information, 2017 Inference is expressed using information and is therefore subject to the limitations of information. The conventions that determine the reliability of inference have developed in information ecosystems under the influence of a range of selection pressures.
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source
ModellingThis article explores the challenges of integrating two deep learning neural networks, YOLOv5 and RT-DETR, to enhance the recognition of unmanned aerial vehicles (UAVs) within the optical-electronic channels of Sensor Fusion systems.
Vladislav Semenyuk +5 more
doaj +1 more source
English Evidential –ly Adverbs in Main Clauses: A Functional Approach
Open Linguistics, 2018 The present paper examines the distribution of English evidential -ly adverb in the scopal hierarchical framework that was presented by Hengeveld and Dall’Aglio Hattnher (2015) in their results of work on Brazilian grammatical evidentials.
Kemp Lois
doaj +1 more source