Results 81 to 90 of about 950,595 (308)
y0-causal-inference/y0: v0.2.6
<h2>What's Changed</h2> <ul> <li>Improve variable sort and CF graph testing by @cthoyt in https://github.com/y0-causal-inference/y0/pull/199</li> <li>Use frozensets for interventions by @cthoyt in https://github.com/y0-
Jeremy Zucker +4 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
This article argues for an alternative analysis of discourse markers to that proposed within relevance-theoretic approaches, which attribute procedural (as opposed to conceptual) meaning to these words.
Alicia Galera Masegosa
doaj +1 more source
Causal network inference using biochemical kinetics [PDF]
Motivation: Networks are widely used as structural summaries of biochemical systems. Statistical estimation of networks is usually based on linear or discrete models.
Bayani, Nora +11 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Inference process is an important part in the architectural design process as well as to realize the different aspects of the product architecture, and plays an important role in bringing new products of an innovator and contrary to traditional ...
Basim Hasan Almajedi +1 more
doaj +1 more source
y0-causal-inference/y0: v0.2.7
<h2>What's Changed</h2> <ul> <li>Add SCM parameter estimation by @cthoyt in https://github.com/y0-causal-inference/y0/pull/201</li> </ul> <p><strong>Full Changelog</strong>: https://github.com/y0 ...
Jeremy Zucker +4 more
core +1 more source
Often scientific information on various data generating processes are presented in the from of numerical and categorical data. Except for some very rare occasions, generally such data represent a small part of the population, or selected outcomes of any ...
Shahjahan Khan, Khan, Shahjahan
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Machine learning methods have achieved good performance and been widely applied in various real-world applications. They can learn the model adaptively and be better fit for special requirements of different tasks.
Zhiqiang Gong, Ping Zhong, Weidong Hu
doaj +1 more source

