Results 101 to 110 of about 950,595 (308)
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Multi-omic approaches for host-microbiome data integration
Gut MicrobesThe gut microbiome interacts with the host through complex networks that affect physiology and health outcomes. It is becoming clear that these interactions can be measured across many different omics layers, including the genome, transcriptome ...
Ashwin Chetty, Ran Blekhman
doaj +1 more source
Deforestation of Functional Programs through Type Inference [PDF]
, 2000 Deforestation optimises a functional program by transforming it into another one that does not create certain intermediate data structures. Short cut deforestation is a deforestation method which is based on a single, local transformation rule. In return,
Chitil, Olaf
core
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Online Algorithms for Hierarchical Inference in Deep Learning applications at the Edge [PDF]
, 2023 We consider a resource-constrained Edge Device (ED) embedded with a small-size ML model (S-ML) for a generic classification application, and an Edge Server (ES) that hosts a large-size ML model (L-ML).
Champati, Jaya Prakash +2 more
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Some Remarks on Consistency and Strong Inconsistency of Bayesian Inference [PDF]
The paper provides new sufficient conditions for consistent and coherent Bayesian inference when a model is invariant under some group of transformations.
Kociecki, Andrzej
core
Indirect inference in spatial autoregression
, 2014 Ordinary least squares (OLS) is well-known to produce an inconsistent estimator of the spatial parameter in pure spatial autoregression (SAR). This paper explores the potential of indirect inference to correct the inconsistency of OLS.
Rossi, Francesca +2 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Improved Decision Module Selection for Hierarchical Inference in Resource-Constrained Edge Devices [PDF]
, 2023 The Hierarchical Inference (HI) paradigm has recently emerged as an effective method for balancing inference accuracy, data processing, transmission throughput, and offloading cost.
Widmer, Joerg +3 more
core