Results 221 to 230 of about 2,162,669 (258)

Editorial Expression of Concern: Stimulation of the endometrium with high-grade blastocyst culture supernatant (SEHB) can improve pregnancy outcome for couples undergoing intracytoplasmic sperm injection (ICSI): a randomized clinical trial

Archives of Gynecology and Obstetrics
Ensieh Shahrokhe Tehraninejad, Fateme Davari Tanha, Mahsa Ghajarzadeh, Zahra Zandieh, Elham Aziminekoo, Haleh Rahmanpour Zanjani   +5 more
doaj   +1 more source

Development and temporal validation of a prediction model for live birth in infertile women with polyendocrine metabolic ovarian syndrome: a retrospective cohort study. [PDF]

Front Reprod Health
Liu P, Wang S, Lu Y, Jia H, Geng Y, Cao C, Han L, Zhou Y.   +7 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Beyond childlessness: a qualitative exploration of the psychosocial impact of infertility among women in Southern Ghana. [PDF]

BMJ Open
Armah D, Kyei J, Ansong-Aggrey SK, Naab F.   +3 more
europepmc   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

Dietary inflammatory index is associated with female infertility: a cross-sectional analysis of the Fasa adults cohort study. [PDF]

BMC Nutr
Zahedi Y, Rahimlou M, Saeed NAAAH, Ranjbar M, Abbasifard M, Tabrizi R.   +5 more
europepmc   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Predicting natural conception leading to live birth for couples with infertility: a single-centre population-based cohort study of 7086 couples. [PDF]

Hum Reprod Open
Cameron NJ, Brian K, McLernon DJ, Bhattacharya S.   +3 more
europepmc   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

The influence of self-compassion on the mental health and well-being of women experiencing infertility: a systematic review. [PDF]

Cogent Ment Health
Othman S, Javanmard M, Roberts L, Conlon L, Steen M.   +4 more
europepmc   +1 more source