Results 101 to 110 of about 1,837,464 (375)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Reactive-infiltration instabilities in rocks. Fracture dissolution

, 2012
A reactive fluid dissolving the surface of a uniform fracture will trigger an instability in the dissolution front, leading to spontaneous formation of pronounced well-spaced channels in the surrounding rock matrix.
Anthony J. C. Ladd, Bird, Boyd, Ebadian, Economides, Monagan, Motyka, Olver, Ortoleva, Piotr Szymczak   +9 more
core   +1 more source

Properties of nanostructured diamond-silicon carbide composites sintered by high pressure infiltration technique [PDF]

, 2004
A high-pressure silicon infiltration technique was applied to sinter diamond–SiC composites with different diamond crystal sizes. Composite samples were sintered at pressure 8 GPa and temperature 2170 K.
G.A. Voronin, T.W. Zerda, J. Gubicza, T. Ungár, S.N. Dub, Khvostantsev, Voronin, Chung, Tomlinson, Voronin, Anatis, Wilkens, Ozbayraktar   +12 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Paradoxes of Subdiffusive Infiltration in Disordered Systems

, 2010
Infiltration of diffusing particles from one material to another where the diffusion mechanism is either normal or anomalous is a widely observed phenomena.
Eli Barkai, I. Podlubny, Nickolay Korabel, S. Redner   +3 more
core   +1 more source

Nanoparticle behaviour in an urban street canyon at different heights and implications on indoor respiratory doses [PDF]

, 2019
The amount of outdoor particles that indoor environments receive depends on the particle infiltration factors (Fin), peculiar of each environment, and on the outdoor aerosol concentrations and size distributions.
Avino, P., Manigrasso, M., Protano, C., Vitali, M.   +3 more
core   +1 more source

Low CD8+ T Cell Infiltration and High PD-L1 Expression Are Associated with Level of CD44+/CD133+ Cancer Stem Cells and Predict an Unfavorable Prognosis in Pancreatic Cancer

Cancers, 2019
Cancer immunotherapy targeting immune checkpoints has exhibited promising clinical outcomes in many cancers, but it offers only limited benefits for pancreatic cancer (PC).
Ya-Chin Hou, Ying-Jui Chao, Min-Hua Hsieh, Hui-Ling Tung, Hao-Chen Wang, Y. Shan   +5 more
semanticscholar   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Laser directed energy deposition of Cu-Cr-Zr alloy: Microstructure evolution and its influence on properties

Materials & Design
Laser directed energy deposited (L-DEDed) Cu alloys present substantial advantages for manufacturing thermal management devices without potential constraints on size.
Yanfang Wang, Chengyu Ma, Yufan Zhao, Gaoyuan Wang, Jiaqiang Li, Wenjun Ma, Yihui Jiang, Shuhua Liang   +7 more
doaj   +1 more source

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

Nature, 2023
Xiaoying Chen, M. Firulyova, Melissa Manis, Jasmin Herz, Igor Smirnov, E. Aladyeva, Chanung Wang, Xin-Chen Bao, M. B. Finn, Hao Hu, I. Shchukina, Min Woo Kim, Carla M. Yuede, J. Kipnis, M. Artyomov, J. Ulrich, D. Holtzman   +16 more
semanticscholar   +1 more source