Results 211 to 220 of about 31,317 (308)

O-to-H Flap Reconstruction of a Central Forehead Defect Following Basosquamous Carcinoma Excision: A Case Report and Literature Review. [PDF]

Cureus
Krili S, Psarras V, Koumoundourou D, Dimitriadou M.   +3 more
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Molecular Differences in Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma (IEFVPTC) and Infiltrative Follicular Variant of Papillary Thyroid Carcinoma (IFVPTC): The Role of Extracellular Matrix. [PDF]

Biomolecules
Sparavelli R, Giannini R, Boldrini L, Fuochi B, Proietti A, Signorini F, Torregrossa L, Materazzi G, Ugolini C.   +8 more
europepmc   +1 more source

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Hormone Receptor-Positive Encapsulated Papillary Carcinoma of the Breast With High-Grade Cytological Features: A Case Report With Invasive Heterogeneity. [PDF]

Am J Case Rep
Liu Y, Shioya A, Haba Y, Inokuchi M, Yamada S.   +4 more
europepmc   +1 more source

A Case of Infiltrating Sinonasal Angiolipoma Accompanied by Invasive Aspergillosis

Journal of Clinical Otolaryngology Head and Neck Surgery, 2012
Dong-Yeop Chang, Dae Woo Kim, Sea-Yuong Jeon, Sang-Wook Kim   +3 more
openaire   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Clinicopathologic Features and Management of Incidentally Detected Sub-centimeter Rectal Neuroendocrine Tumors: A Case Series. [PDF]

Cureus
Kaur T, Galani HG, Andriashvili G, Dogra N, Houston PM, Williams G.   +5 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Beyond Resection: Surgery as an Evolutionary Bottleneck Shaping Tumor Evolution and Treatment Response in Diffuse Gliomas. [PDF]

Cancers (Basel)
Tini P, Donnini F, Rubino G, Battaglia G, Pastina P, Vannini M, Carfagno T, Tiezzi G, Cellini L, Minniti G, Chibbaro S.   +10 more
europepmc   +1 more source