Results 41 to 50 of about 17,191 (264)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Reachability Analysis of Reversal-bounded Automata on Series-Parallel Graphs [PDF]

Electronic Proceedings in Theoretical Computer Science, 2015
Extensions to finite-state automata on strings, such as multi-head automata or multi-counter automata, have been successfully used to encode many infinite-state non-regular verification problems.
Rayna Dimitrova, Rupak Majumdar
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Unordered Love in infinite directed graphs

International Journal of Mathematics and Mathematical Sciences, 1992
A digraph D=(V,A) has the Unordered Love Property (ULP) if any two different vertices have a unique common outneighbor. If both (V,A) and (V,A−1) have the ULP, we say that D has the SDULP.
Peter D. Johnson
doaj   +1 more source

On Laplacian Equienergetic Signed Graphs

Journal of Mathematics, 2021
The Laplacian energy of a signed graph is defined as the sum of the distance of its Laplacian eigenvalues from its average degree. Two signed graphs of the same order are said to be Laplacian equienergetic if their Laplacian energies are equal.
Qingyun Tao, Lixin Tao
doaj   +1 more source

On the distance spectrum of certain distance biregular graphs

The American Journal of Combinatorics, 2023
In this article we present an infinite family of bipartite distance biregular graphs having an arbitrarily large diameter and whose distance matrices have exactly four distinct eigenvalues. This result answers a question posed by F.
Miriam Abdon, Tayna Lobo, Renata Del-Vecchio   +2 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Pair L(2, 1)-Labelings of Infinite Graphs

Discussiones Mathematicae Graph Theory, 2019
An L(2, 1)-labeling of a graph G = (V,E) is an assignment of nonnegative integers to V such that two adjacent vertices must receive numbers (labels) at least two apart and further, if two vertices are in distance 2 then they receive distinct labels. This
Yeh Roger K.
doaj   +1 more source

On Resolvability- and Domination-Related Parameters of Complete Multipartite Graphs

Mathematics, 2022
Graphs of order n with fault-tolerant metric dimension n have recently been characterized.This paper points out an error in the proof of this characterization. We show that the complete multipartite graphs also have the fault-tolerant metric dimension n,
Sakander Hayat, Asad Khan, Yubin Zhong
doaj   +1 more source