Results 51 to 60 of about 732,643 (255)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Coarse Geometry of Pure Mapping Class Groups of Infinite Graphs [PDF]
, 2022 We discuss the large-scale geometry of pure mapping class groups of locally finite, infinite graphs, motivated by recent work of Algom-Kfir--Bestvina and the work of Mann--Rafi on the large-scale geometry of mapping class groups of infinite-type surfaces.
Kwak, Sanghoon +5 more
core +1 more source
Pair L(2, 1)-Labelings of Infinite Graphs
Discussiones Mathematicae Graph Theory, 2019 An L(2, 1)-labeling of a graph G = (V,E) is an assignment of nonnegative integers to V such that two adjacent vertices must receive numbers (labels) at least two apart and further, if two vertices are in distance 2 then they receive distinct labels. This
Yeh Roger K.
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Unavoidable Structures in Large and Infinite Graphs [PDF]
, 2022 In this work, we present results on the unavoidable structures in large connected and large 2-connected graphs. For the relation of induced subgraphs, Ramsey proved that for every positive integer r, every sufficiently large graph contains as an induced ...
Allred, Sarah, Sarah Allred, null null
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Reachability Analysis of Reversal-bounded Automata on Series-Parallel Graphs [PDF]
Electronic Proceedings in Theoretical Computer Science, 2015 Extensions to finite-state automata on strings, such as multi-head automata or multi-counter automata, have been successfully used to encode many infinite-state non-regular verification problems.
Rayna Dimitrova, Rupak Majumdar
doaj +1 more source