Results 41 to 50 of about 280,214 (233)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Spectral partitions on infinite graphs

open access: yes, 2000
Statistical models on infinite graphs may exhibit inhomogeneous thermodynamic behaviour at macroscopic scales. This phenomenon is of geometrical origin and may be properly described in terms of spectral partitions into subgraphs with well defined ...
Alexander S   +8 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Reachability Analysis of Reversal-bounded Automata on Series-Parallel Graphs [PDF]

open access: yesElectronic Proceedings in Theoretical Computer Science, 2015
Extensions to finite-state automata on strings, such as multi-head automata or multi-counter automata, have been successfully used to encode many infinite-state non-regular verification problems.
Rayna Dimitrova, Rupak Majumdar
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Unordered Love in infinite directed graphs

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1992
A digraph D=(V,A) has the Unordered Love Property (ULP) if any two different vertices have a unique common outneighbor. If both (V,A) and (V,A−1) have the ULP, we say that D has the SDULP.
Peter D. Johnson
doaj   +1 more source

On Laplacian Equienergetic Signed Graphs

open access: yesJournal of Mathematics, 2021
The Laplacian energy of a signed graph is defined as the sum of the distance of its Laplacian eigenvalues from its average degree. Two signed graphs of the same order are said to be Laplacian equienergetic if their Laplacian energies are equal.
Qingyun Tao, Lixin Tao
doaj   +1 more source

On Resolvability- and Domination-Related Parameters of Complete Multipartite Graphs

open access: yesMathematics, 2022
Graphs of order n with fault-tolerant metric dimension n have recently been characterized.This paper points out an error in the proof of this characterization. We show that the complete multipartite graphs also have the fault-tolerant metric dimension n,
Sakander Hayat, Asad Khan, Yubin Zhong
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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