Results 41 to 50 of about 200,479 (255)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A characterization of higher rank symmetric spaces via bounded cohomology
, 2008 Let $M$ be complete nonpositively curved Riemannian manifold of finite volume whose fundamental group $\Gamma$ does not contain a finite index subgroup which is a product of infinite groups.
Bestvina, Mladen, Fujiwara, Koji
core +1 more source
FEBS Open Bio, EarlyView.This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source
Spectral properties of a class of random walks on locally finite groups
, 2011 We study some spectral properties of random walks on infinite countable amenable groups with an emphasis on locally finite groups, e.g. the infinite symmetric group.
Bendikov, Alexander +2 more
core +3 more sources
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source
On Discreteness of Commensurators
, 2010 We begin by showing that commensurators of Zariski dense subgroups of isometry groups of symmetric spaces of non-compact type are discrete provided that the limit set on the Furstenberg boundary is not invariant under the action of a (virtual) simple ...
Fathi +12 more
core +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Symmetric groups and checker triangulated surfaces
, 2017 We consider triangulations of surfaces with edges painted three colors so that edges of each triangle have different colors. Such structures arise as Belyi data (or Grothendieck dessins d'enfant), on the other hand they enumerate pairs of permutations ...
Neretin, Yury A.
core +2 more sources
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source