Results 41 to 50 of about 221,589 (315)

The Lagrangian Conley Conjecture

, 2010
We prove a Lagrangian analogue of the Conley conjecture: given a 1-periodic Tonelli Lagrangian with global flow on a closed configuration space, the associated Euler-Lagrange system has infinitely many periodic solutions.
Mazzucchelli, Marco
core   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Infinitely many positive solutions for a double phase problem

Boundary Value Problems, 2020
This paper is concerned with the existence of infinitely many positive solutions to a class of double phase problem. By variational methods and the theory of the Musielak–Orlicz–Sobolev space, we establish the existence of infinitely many positive ...
Bei-Lei Zhang, Bin Ge, Gang-Ling Hou
doaj   +1 more source

INFINITELY MANY SOLUTIONS FOR FRACTIONAL SCHRÖDINGER-MAXWELL EQUATIONS

Journal of Applied Analysis & Computation, 2019
Summary: In this paper using fountain theorems we study the existence of infinitely many solutions for fractional Schrödinger-Maxwell equations \[ \begin{cases} (-\Delta)^\alpha u+\lambda V(x)u+\phi u=f(x,u)-\mu g(x)|u|^{q-2}u, \text{in } \mathbb R^3, \\ (-\Delta)^\alpha \phi=K_\alpha u^2, \text{in } \mathbb{R}^3, \end{cases} \] where \(\lambda,\mu >0\)
Xu, Jiafa, Wei, Zhongli, O'Regan, Donal, Cui, Yujun   +3 more
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Ground state solutions and infinitely many solutions for a nonlinear Choquard equation

Boundary Value Problems, 2021
In this paper we study the existence and multiplicity of solutions for the following nonlinear Choquard equation: − Δ u + V ( x ) u = [ | x | − μ ∗ | u | p ] | u | p − 2 u , x ∈ R N , $$\begin{aligned} -\Delta u+V(x)u=\bigl[ \vert x \vert ^{-\mu }\ast ...
Tianfang Wang, Wen Zhang
doaj   +1 more source

Bayesian Estimation Improves Prediction of Outcomes After Epilepsy Surgery

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We estimated the statistical power of studies predicting seizure freedom after epilepsy surgery. We extracted data from a Cochrane meta‐analysis. The median power across all studies was 14%. Studies with a median sample size or less (n ≤ 56) and a statistically significant result exaggerated the true effect size by a factor of 5.4, while the ...
Adam S. Dickey, Vineet Reddy, Ammar A. Rashied, Nigel P. Pedersen, Robert T. Krafty   +4 more
wiley   +1 more source

Poly(1,4‐anthraquinone) as an Organic Electrode Material: Interplay of the Electronic and Structural Properties due to the Unusual Lone‐Pair‐π Conjugation

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
In this study, the unique role of the unusual lone‐pair‐π conjugation mechanism in poly(1,4‐anthraquinone) (P14AQ) is explored as an organic electrode material. Unlike traditional π‐π interactions, P14AQ's conjugation involves lone pairs of oxygen atoms interacting with the π cloud of adjacent units, enabling stable charge transport even with minimal π‐
Xiaotong Zhang, Piotr de Silva
wiley   +1 more source

Infinitely many solutions for semilinear nonlocal elliptic equations under noncompact settings [PDF]

, 2015
In this paper, we study a class of semilinear nonlocal elliptic equations posed on settings without compact Sobolev embedding. More precisely, we prove the existence of infinitely many solutions to the fractional Brezis-Nirenberg problems on bounded ...
Choi, Woocheol, Seok, Jinmyoung
core